Thermoresponsive Hydrogel Microvalve Based on Magnetic Nanoheaters for Microfluidics
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1095-EE03-20
Thermoresponsive Hydrogel Microvalve Based on Magnetic Nanoheaters for Microfluidics Santaneel Ghosh1, Arup Neogi2, Chao Yang2, Tong Cai2, Somesree GhoshMitra3, David Diercks2, and Zhibing Hu2 1 Physics and Engineering Physics, Southeast Missouri State University, One University Plaza, MS 6600, Cape Girardeau, MO, 63701 2 University of North Texas, Denton, TX, 76203 3 Texas Woman's University, Denton, TX, 76201
ABSTRACT
A novel magneto-active gel based nanomaterial system is presented as an externally tunable flow controller inside a microfluidic channel using the thermoresponsive property of the structure. Integration of ferromagnetic nanoparticles (Fe3O4) in the temperature sensitive polymer-poly (N-isopropylacrylamide) (PNIPAM) provides the swelling and de-swelling behavior of magnetic stimuli controlled micro-component by generating the heat due to the hysteresis loss of Fe3O4 under exposure in an alternating magnetic field. The shrinkage rates of the nanomaterial system at the bulk and micro scale are investigated. Size dependent shrinkage rate and actuation efficiency are ideal for various applications like magnetic micro/nano pump, magnetic field controlled drug delivery devices and magnetic switch applications.
INTRODUCTION In the last ten years, there has been an explosion of advances in the fields of structured and intelligent materials science and based on derived and tunable nanomaterial properties, micro/nano devices have been constantly amended so as to make it more comprehensive. The ability to actively manipulate fluid-flow patterns through microfluidic devices is important to many current applications and vital to the development of more complex systems in the future. The small volume of sample and fast response are the primary features of the microfluidic systems. The working principle of a typical actively controlled valve to date relies on its mechanical or electromagnetic properties. However, the issues of biocompatibility, packaging and mechanical/electrical integration, actuation and multifunctionality lead to the search for smarter valve materials with enhanced actuation efficiency and better performance level. Magnetic responsive hydrogels has become an interesting subject of study as they offer several potential advantages over other material systems for the controlled release of drugs, local heating of the target region leaving all other regions unaffected and the temperature control within as well as outside the target region due to their response to the magnetic stimuli. Because of the hysterisis loss from the magnetic nano particles, temperature of the system goes up, and once the temperature crosses the lower critical solution temperature (LCST), the thermoresponsive gel goes under large contraction. In this present work, the goal is to design a
microvalve in combination with drug delivery. The idea is to develop a magnetic and hydrogel nanocomposite material whereby the magnetic material will be responsible for heating up the system and the de-swelled hydrogel will
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