Thyroid Hormone Disruption and Neurodevelopment
Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. How
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Noriyuki Koibuchi Paul M. Yen Editors
Thyroid Hormone Disruption and Neurodevelopment
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Contemporary Clinical Neuroscience
More information about this series at http://www.springer.com/series/7678
Noriyuki Koibuchi • Paul M. Yen Editors
Thyroid Hormone Disruption and Neurodevelopment
Editors Noriyuki Koibuchi Department of Integrative Physiology Gunma University Graduate School of Medicine Maebashi, Gunma, Japan
Paul M. Yen Laboratory of Hormonal Regulation Cardiovascular and Metabolic Disorders Program Duke-NUS Graduate Medical School Singapore, Singapore
Contemporary Clinical Neuroscience ISBN 978-1-4939-3735-6 ISBN 978-1-4939-3737-0 DOI 10.1007/978-1-4939-3737-0
(eBook)
Library of Congress Control Number: 2016940093 © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Contents
Part I
Disruption of Thyroid Hormone Action at Molecular Level
1
Mechanisms for Thyroid Hormone Action in the CNS ....................... Rohit Anthony Sinha and Paul. M. Yen
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2
Deiodinase and Brain Development ...................................................... Masami Murakami
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3
Brominated Organohalogens and Neurodevelopment: Different Mechanisms, Same Consequence .......................................... Kingsley Ibhazehiebo, Toshiharu Iwasaki, and Noriyuki Koibuchi
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Perinatal Infection-Associated Changes in Thyroid Hormone Status, Gut Microbiome, and Thyroid Hormone-Mediated Neurodevelopment ............................................... E.M. Sajdel-Sulkowska, M. Bialy, and R. Zabielski Disruption of Feedback Regulation of Thyroid Hormone Synthesis/Secretion and Brain Development ........................................ Sumiyasu Ishii and Masanobu Yamada
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Part II Animal Models to Stu
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