Thyroid Hormone Nuclear Receptor Methods and Protocols
This volume aims to detail the advances in the field of Thyroid hormones (THs), namely T3 and T4, and their nuclear receptor TRs from a conceptual and methodological point of view. Chapters guide readers through a general introduction, TR's engineered mic
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Michelina Plateroti Jacques Samarut Editors
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Thyroid Hormone Nuclear Receptor Methods and Protocols
Methods
in
M o l e c u l a r B i o lo g y
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Thyroid Hormone Nuclear Receptor Methods and Protocols
Edited by
Michelina Plateroti Centre Léon Bérard, Cancer Research Center of Lyon, Lyon, France
Jacques Samarut École normale supérieure de Lyon , Lyon, France
Editors Michelina Plateroti Centre Léon Bérard Cancer Research Center of Lyon Lyon, France
Jacques Samarut École normale supérieure de Lyon Lyon, France
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7901-1 ISBN 978-1-4939-7902-8 (eBook) https://doi.org/10.1007/978-1-4939-7902-8 Library of Congress Control Number: 2018943137 © Springer Science+Business Media, LLC, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Thyroid hormones (THs), namely T3 and T4, play a fundamental role in the development, growth, and metabolic homeostasis in all vertebrates by affecting the expression of multiple genes. As a consequence, an altered thyroid status affects many organs and systems. TH’s action is mediated mainly by the T3 receptors (TRs), which belong to the nuclear hormone receptor superfamily of transcription factors. Interestingly, the THs and the TRs are also present in nonvertebrates, opening to important questions concerning their function in simpler animals as well as their role along the
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