Time course of changes in contrast sensitivity following intravitreal ranibizumab injection for branch retinal vein occl
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CLINICAL INVESTIGATION
Time course of changes in contrast sensitivity following intravitreal ranibizumab injection for branch retinal vein occlusion Yoshimi Sugiura1 · Fumiki Okamoto1 · Tomoya Murakami1 · Shohei Morikawa1 · Takahiro Hiraoka1 · Tetsuro Oshika1 Received: 16 August 2019 / Accepted: 14 May 2020 © Japanese Ophthalmological Society 2020
Abstract Purpose To evaluate contrast sensitivity (CS) in patients with branch retinal vein occlusion (BRVO) following intravitreal ranibizumab injection (IVR), and to investigate the relationship between CS and retinal microstructure. Design A retrospective, observational case series. Methods We included 23 eyes with treatment naïve BRVO followed up for 6 months after treatment. Best-corrected visual acuity (BCVA), letter contrast sensitivity (LC), and 10% low contrast visual acuity (LCVA) were measured. All tests were performed before and 1, 2, 3, 4, 5, and 6 months after treatment. Based on optical coherence tomography (OCT) images, we assessed central retinal thickness (CRT), presence of serous retinal detachment (SRD), and status of the external limiting membrane (ELM) and ellipsoid zone (EZ). Results IVR treatment significantly improved CS (LC: P
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