Tooth loss and adiposity: possible role of carnitine transporter (OCTN1/2) polymorphisms in women but not in men

  • PDF / 374,792 Bytes
  • 9 Pages / 595.276 x 790.866 pts Page_size
  • 93 Downloads / 141 Views

DOWNLOAD

REPORT


ORIGINAL ARTICLE

Tooth loss and adiposity: possible role of carnitine transporter (OCTN1/2) polymorphisms in women but not in men Peter Meisel 1

&

Stefanie Pagels 1,2 & Markus Grube 2 & Gabriele Jedlitschky 2 & Henry Völzke 3 & Thomas Kocher 1

Received: 7 May 2020 / Accepted: 15 September 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020

Abstract Objective SLC22A4/5 single nucleotide polymorphisms (SNPs) have been reported to affect inflammatory diseases. We report the relationship of these polymorphisms with adiposity and tooth loss as elucidated in a 10-year follow-up study. Methods Participants of the Study of Health in Pomerania (SHIP, N = 4105) were genotyped for the polymorphisms c.1507C > T in SLC22A4 (rs1050152) and -207C > G in SLC22A5 (rs2631367) using allele-specific real-time PCR assays. A total of 1817 subjects, 934 female and 883 male aged 30–80 years, underwent follow-up 10 years later (SHIP-2) and were assessed for adiposity and tooth loss. Results The frequencies of the rarer SLC22A4 TT and SLC22A5 CC alleles were 16.7% and 20.3%, respectively. In women, tooth loss was associated with genotype TT vs. CC with incidence rate ratio IRR = 0.74 (95%C.I. 0.60–0.92) and CC vs. GG IRR = 0.79 (0.65–0.96) for SLC22A4 and SLC22A5 SNPs, respectively. In men, no such associations were observed. In the follow-up examination, the relationship between tooth loss and these SNPs was in parallel with measures of body shape such as BMI, body weight, waist circumference, or body fat accumulation. The association between muscle strength and body fat mass was modified by the genotypes studied. Conclusions SLC22A4 c.150C > T and SLC22A5 -207C > G polymorphisms are associated with tooth loss and markers of body shape in women but not in men. Clinical relevance Tooth loss may be related to obesity beyond inflammatory mechanisms, conceivably with a genetic background. Keywords Tooth loss . OCTN1/2 . Polymorphism . Obesity . Sex . Carnitine

Introduction

Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00784-020-03594-w) contains supplementary material, which is available to authorized users. * Peter Meisel [email protected] 1

Department of Periodontology, Dental Clinics, Dental School, University Medicine Greifswald, Fleischmannstrasse 42, 17475 Greifswald, Germany

2

Department of Pharmacology of the Center of Drug Absorption and Transport (C_DAT), University Medicine Greifswald, Greifswald, Germany

3

Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

In our functional studies on human membrane transporter proteins [1], we detected the expression of the organic cation transporters novel (OCTNs) in human gingival tissues by histochemical means. Taking this expression as a prerequisite, we observed a polymorphic gene-dose effect of the OCTNs on adiposity and tooth loss in a general population study. Various studies reported associations between obesity and tooth loss but a common genetic background is not known