Transcutaneous oxygen pressure-related variables as noninvasive indicators of low lactate clearance in sepsis patients a
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ORIGINAL RESEARCH
Transcutaneous oxygen pressure‑related variables as noninvasive indicators of low lactate clearance in sepsis patients after resuscitation Liang Xu1 · Minjia Wang1 · Shijin Gong1 · Cong Ye1 · Liang Wu1 Received: 24 April 2020 / Accepted: 18 September 2020 © Springer Nature B.V. 2020
Abstract The transcutaneous oxygen challenge test (OCT) is associated with central venous oxygen saturation and cardiac output index, and has predictive value for prognosis. Whether the change of transcutaneous oxygen pressure (PtcO2)-related variables can reflect lactate clearance in sepsis patients is worth studying. We conducted a prospective observational study of 79 patients with sepsis or septic shock in the ICU. Immediately after enrollment, P tcO2 monitoring was continuously performed for 6 h. The OCT was performed at enrollment (T0) and the sixth hour (T6). The correlation between lactate clearance and PtcO2-related variables such as PtcO2 at T6, ΔPtcO2 (PtcO2 at T6 − PtcO2 at T0), ΔPtcO2 index (PtcO2/PaO2 at T6 − PtcO2/PaO2 at T0), 10 OCT [(PtcO2 after 10 min on FiO2 of 1.0) − (PtcO2 at baseline)], Δ10 OCT (10 OCT at T6 − 10 OCT at T0) was analyzed. The difference of P tcO2-related variables was compared between the high and low lactate clearance groups. P tcO2 at T6 (r = 0.477, p
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