Transitional cell carcinoma of the ovary: A rare case and review of literature
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WORLD JOURNAL OF SURGICAL ONCOLOGY
CASE REPORT
Open Access
Transitional cell carcinoma of the ovary: A rare case and review of literature EM Tazi1*, I Lalya1, MF Tazi2, Y Ahellal2, H M’rabti1, H Errihani1
Abstract Introduction: Transitional cell carcinoma (TCC) of the ovary is a rare, recently recognized, subtype of ovarian surface epithelial cancer. Case presentation: A 69-year-old postmenopausal woman presented with a 2-year history of progressive enlargement of an abdominal mass. Abdominal computed tomography showed a pelvic mass. CA-125 was normal. A staging operation with total abdominal hysterectomy, bilateral salpingo-oophorectomy, infracolic omentectomy and pelvic lymph node dissection was performed. After surgery, the pathologic report of the right ovarian tumour was TCC, grade 3, stage IC. The patient underwent 3 cycles of chemotherapy: carboplatin and paclitaxel. She is regularly followed up and has been disease free for 10 months Conclusion: Transitional cell carcinoma (TCC) of the ovary is a rare subtype of epithelial ovarian cancer. Surgical resection is the primary therapeutic approach, and patient outcomes after chemotherapy are better than for other types of ovarian cancers.
Introduction Transitional cell carcinoma (TCC) of the ovary is a rare, recently recognized, subtype of ovarian surface epithelial cancer. In a study by Silva et al, focal or diffuse TCC pattern was seen in 88 of 934 ovarian cancers [1]. Here, we present a case of TCC of the ovary, managed by total abdominal hysterectomy and bilateral salpingooophorectomy with infracolic omentectomy and pelvic lymph node dissection followed by chemotherapy. Case presentation A 69-year-old postmenopausal woman presented with a 2-year history of progressive enlargement of an abdominal mass. She had experienced weight loss of about 4 kg during the 6 months prior to admission. Physical examination showed a pelvic mass. Abdominal ultrasound showed a pelvic mass measuring 31 × 35 mm with homogeneous echogenicity. Abdominal computed tomography (CT) showed a homogeneous cyst on the right side of the pelvis, which was larger than 35 mm in maximal diameter with a solid component. There was no evidence of * Correspondence: [email protected] 1 Departement of Medical Oncology, National Institute of Oncology, Rabat, Morocco Full list of author information is available at the end of the article
lymphadenopathy. The liver and kidneys were unremarkable (Figure 1). Routine biologic test results were all within normal ranges. Initial investigation of tumor markers before surgery showed normal serum CA-125 (5.3 U/mL; normal, 0-35 U/mL). She underwent surgery under the impression of malignant ovarian tumor. A small amount of ascites (about 100 mL) in the pelvic cavity was found intraoperatively. A cystic mass, measuring 3, 5 × 1.5 cm, arising from the right ovary; was resected. There was no enlargement of the paraaortic lymph node on palpation. Therefore, surgical staging procedures including total abdominal hysterectomy, bilateral salpingo-oophorectomy,
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