Transplantation
Transplantation is defined as the transfer of living cells, tissues, or organs from one site to another in the same individual (syngeneic transplantation) or from one individual to another — of the same (allogeneic transplantation) or another (xenogeneic
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Fundamentals of Immunology Completely Revised Second Edition With a Contribution by Reinhard Burger
With 173 Figures
Springer-Verlag Berlin Heidelberg New York London Paris Tokyo
DR. OTTO G. BIER t Laborat6rio Especial de Imunologia Aplicada Instituto Butantan, Sao Pau1o, SP., Brazil Dr. WILMAR DIAS DA SILVA Instituto de Biociencias, Departamento de Microbiologia e Imunologia Cidade Universitaria, Sao Pau1o, SP., Brazil Formerly Center for Blood Research, Boston, MA, USA Dr. med. habil. DIETRICH GOTZE University Medical School, Heidelberg, FRG Formerly Associate Professor of Immunology The Wistar Institute - The University of Pennsylvania Philadelphia, PA, USA Dr. IVAN MOTA Centro de Imunologia da OMSjOPS, Instituto Butantan CPo 65, Sao Pau1o, SP., Brazil Contributor: Dr. med. habil. REINHARD BURGER University Medical School Heidelberg Institut fiir Immunologie und Serologie 1m Neuenheimer Feld 305, Heidelberg, FRG
Cover page figure: schematic representation of the T cell antigen receptor (TAR) chains in the cell membrane associated with the CD3 ("I, f>, 8) molecule
C(
and f3
ISBN -13: 978-3-540-15332-0 e- ISBN -13: 978-3-642-70393-5 DOl: 10.1007/978-3-642-70393-5
Library of Congress Cataloging-in-Publication Data. Fundamentals of immunology. Includes bibliographies and indexes. 1. Immunology. I. Bier, Otto, 1906--. QRI81.F851986 616.07'9 86-17881 ISBN-13:978-3-540-15332-0 (U.S.) This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under § 54 of the German Copyright Law, where copies are made for other than private use, a fee is payable to "Verwertungsgesellschaft Wort", Munich. © 1981by Springer-Verlag New York Inc. © Springer-Verlag Berlin Heidelberg 1986 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product Liability: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. 2127/3130-543210
Preface to the Second Edition
The good acceptance of this textbook is an indication that it has served its purpose. The present edition has been prepared in order to cover the main progress achieved in the five years that have elapsed since the first edition. The structure of the book remains essentially the same but a considerable amount of new material has been introduced, particularly in certain areas such as the genetics of immunoglobulins and T cell receptor, the regulation of the immune response, hypersensitivity reactions, and cellular immunology. Today, immunology is essential for biologists in general and in partic
