Treatment of children with COVID-19: position paper of the Italian Society of Pediatric Infectious Disease
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(2020) 46:139
REVIEW
Open Access
Treatment of children with COVID-19: position paper of the Italian Society of Pediatric Infectious Disease Elisabetta Venturini1†, Carlotta Montagnani1†, Silvia Garazzino2, Daniele Donà3, Luca Pierantoni4, Andrea Lo Vecchio5, Giangiacomo Nicolini6, Sonia Bianchini7, Andrzej Krzysztofiak8, Luisa Galli9, Alberto Villani8, Guido Castelli-Gattinara8* and for the Italian SITIP-SIP SARS-Cov-2 pediatric infection study group
Abstract A statement of consensus was formulated after reviewing available literature on pediatric treatment strategies for COVID-19 by the Steering and Scientific Committee of the Italian Society of Infectious Pediatric Diseases in connection with the Italian Society of Paediatrics. Keywords: COVID-19, SARS CoV-2, Children, Treatment
Background Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been reported in Hubei province, China, and from there it spread worldwide. Starting from the end of February 2020, the number of cases of coronavirus disease 2019 (COVID-19) outside China rapidly increased, urging the World Health Organization (WHO) to declare COVID-19 as a pandemic on March 11 [1]. Most children with SARS-CoV-2 infection develop none or mild symptoms, needing only supportive treatment [2, 3]. However, few cases of severe COVID-19 in children have been reported [3–5], including multisystem inflammatory syndromes [6, 7]. As no evidence of at least good quality is available regarding therapy of COVID-19, treatment regimens of COVID-19 are not standardized. At present, few clinical * Correspondence: [email protected] † Venturini Elisabetta and Montagnani Carlotta contributed equally to this work. 8 Universitarian-Hospital Department Ospedale Bambino Gesù IRCCS, Rome, Italy Full list of author information is available at the end of the article
trials for COVID-19 treatment involving children are ongoing [8]. Moreover, evidences are rapidly evolving and the therapeutic indications can change very quickly and even this work has changed quite a bit in the course of its writing. To date, many national and international guidelines have been issued for the adult population [9–11]. However, there is a need of guidance on COVID-19 management in children from scientific societies and expert groups. Recently, an expert opinion has been released by a group of pediatric infectious disease specialists from North America, suggesting that supportive care alone is indicated for the overwhelming majority of cases [12]. The Italian Society of Pediatric Infectious Diseases steering and scientific committee developed a position paper on treatment of children with COVID-19, reviewing the current literature on this topic and providing indications based on the available literature data. Since new evidences will be available in the next weeks/months, the Italian Society of Pediatric Infectious Diseases will guarantee to maintain treatment indication
© The Author(s). 2020 Open Access This article is licensed under a Creative Common
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