Treatment outcome and long-term follow-up of central nervous system germ cell tumor using upfront chemotherapy with subs
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RESEARCH ARTICLE
Open Access
Treatment outcome and long-term followup of central nervous system germ cell tumor using upfront chemotherapy with subsequent photon or proton radiation therapy: a single tertiary center experience of 127 patients Kyung Taek Hong1,2,3†, Da Hye Lee2†, Bo Kyung Kim1,2,3, Hong Yul An1,2,3, Jung Yoon Choi1,2,3, Ji Hoon Phi4,5, Jung-Eun Cheon6, Hyoung Jin Kang1,2,3, Seung-Ki Kim4,5, Joo-Young Kim7, Sung-Hye Park8, Il Han Kim3,9 and Hee Young Shin1,2,3,10*
Abstract Background: Central nervous system germ cell tumors (CNS GCTs) are a heterogeneous group of brain tumors, which are more common in Asian countries. There have been different therapeutic strategies in treating germinoma and non-germinomatous germ cell tumors (NGGCT), depending on prognosis. Moreover, long-term follow up should be emphasized due to higher late complication rates. Here, we investigated long-term outcomes and complication profiles of 127 CNS GCT patients who received uniform upfront chemotherapy. Methods: We retrospectively evaluated outcomes of CNS GCT patients treated in Seoul National University Children’s Hospital from August 2004 to April 2019. Patients were classified as low risk (LR) or high risk (HR) based on pathologic diagnosis and tumor markers. Most patients received upfront systemic chemotherapy with carboplatin, cyclophosphamide, etoposide, and/or bleomycin, followed by either proton or photon radiation therapy according to patients’ choice. (Continued on next page)
* Correspondence: [email protected] † Kyung Taek Hong and Da Hye Lee contributed equally to this work. 1 Departments of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea 2 Division of Pediatrics, Seoul National University Children’s Hospital, Seoul, Republic of Korea Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Hong et al. BMC Cancer
(2020) 20:979
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Results: The median ag
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