Treatment
Worldwide networks of MSA researchers have been focusing their efforts on developing disease-modifying therapies for MSA, but so far no curative, or even specific symptomatic, therapy has been discovered. Therapeutic measures in MSA are currently based on
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Multiple System Atrophy
Gregor K. Wenning • Alessandra Fanciulli Editors
Multiple System Atrophy
Editors Gregor K. Wenning, MD, PhD, MSC Division of Neurobiology Department of Neurology Innsbruck Medical University Innsbruck Austria
Alessandra Fanciulli, MD Department of Neuroscience, Mental Health and Sensory Organs “Sapienza” University of Rome Rome Italy Division of Neurobiology Department of Neurology Innsbruck Medical University Innsbruck Austria
ISBN 978-3-7091-0686-0 ISBN 978-3-7091-0687-7 DOI 10.1007/978-3-7091-0687-7 Springer Wien Heidelberg Dordrecht London New York
(eBook)
Library of Congress Control Number: 2013949517 © Springer-Verlag Wien 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher's location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Foreword
Multiple system atrophy (MSA) is one of the most challenging diseases within the spectrum of neurodegenerative movement disorders. Early accurate diagnosis is almost impossible on clinical grounds where the parkinsonian variant of MSA can be so strikingly similar to idiopathic Parkinson’s disease, that initial misclassification is common even in the hands of highly specialised movement disorder experts. When presenting as a cerebellar syndrome, MSA may hide for years behind the screen of conditions subsumed under the label of idiopathic late-on
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