TROP2 is a Good Indicator for Infiltrative Nature of Carcinoma Rather than Diagnosing Malignancy in Thyroid
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ORIGINAL ARTICLE
TROP2 is a Good Indicator for Infiltrative Nature of Carcinoma Rather than Diagnosing Malignancy in Thyroid E. Kılınc1
•
P. Gunes2 • A. Doganer3
Received: 8 October 2020 / Accepted: 9 November 2020 Ó Association of Otolaryngologists of India 2020
Abstract TROP2 is a glycoprotein which is expressed in carcinomas rather than normal tissues and associated with poor prognosis. Immunohistohemical TROP2 staining was determined to be useful for diagnosing papillary thyroid carcinoma (PTC). In this study, we aimed to find out relationship between TROP-2 expression and the diagnosis of PTC, and clinico pathological parameters. This retrospective study was conducted on 270 cases (145 malignant and 124 benign). All histopathological parameters were reevaluated blindly. We used 3 different scores for positivity for TROP2 expression (TES: Total estimation score, 5%, IRS:Immunoreactive score). Sensitivity was respectively according to TES, 5%and IRS; 55.5%, 54.1%, 51.4%. Specificity was 98.4% in all different scores. TROP2 positivity was correlated with older age in 5% score and TES. Absence of encapsulation, presence of infiltrating spreading, perineural invasion, extra thyroidal extension, tall cell and/or hobnail differentiation were associated with TROP2 expression in three different scores. Presence of lymphatic invasion was correlated with TROP2 positivity in 5% score and IRS. TROP2 expression was inversely proportional to follicular variant PTC and tumour size in 5% score. TROP-2 is a marker for aggressive behaviour rather than detecting malignancy, but if it stained and not malignant, it may also have potential for determining & E. Kılınc [email protected] 1
Pathology Department, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey
2
Pathology Department, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey
3
Biostatistics Department, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey
precursor lesion that demands further studies. Additionally, in 3 different scores, TES was most sensitive, but most variable that had correlation with TROP2 was seen at 5% score. Keywords TROP2 Thyroid carcinoma Immunohistochemistry Aggresive behavior
Introduction Human trophoblastic cell-surface antigen 2 (TROP2) is a transmembrane glycoprotein which is expressed in carcinomas rather than normal tissues and associated with poor prognosis [1–3].This protein is related to tumor progression and metastasis via regulating the phosphatidylinositol 3 kinase(PI3K)/protein kinase B pathway causing epithelialmesenchymal transition [4]. TROP2 also increase invasion due to activation of MAPK (mitogen-activated protein kinase) in thyroid [5]. PI3K and MAPK pathway are affected in thyroid malignancy [6]. Papillary thyroid carcinomas(PTC) is most frequent thyroid carcinomas and mostly have good prognosis, however infrequently recurrence, metastasis and radioiodine resistance can happen, so new markers are required to determine the aggressiveness of each individual case and to make targeted
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