TRP Channels in Drug Discovery Volume II
Recent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options. Thus, the TRP superfamily of ion channels ha
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IN
PHARMACOLOGY
AND
Series Editor Y. James Kang
For further volumes: http://www.springer.com/series/7653
TO X I C O L O G Y
TRP Channels in Drug Discovery Volume II
Edited by
Arpad Szallasi Monmouth Medical Center, Long Branch, NJ, USA
Tamás Bíró Medical and Health Science Center, Department of Physiology, University of Debrecen, Debrecen, Hungary
Editors Arpad Szallasi Monmouth Medical Center Long Branch, NJ, USA
Tamás Bíró Medical and Health Science Center Department of Physiology University of Debrecen Debrecen, Hungary
ISSN 1557-2153 ISSN 1940-6053 (electronic) ISBN 978-1-62703-094-6 ISBN 978-1-62703-095-3 (eBook) DOI 10.1007/978-1-62703-095-3 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2012947027 © Springer Science+Business Media, LLC 2012 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is a brand of Springer Springer is part of Springer Science+Business Media (www.springer.com)
Preface With almost 600 reviews, Transient Receptor Potential (TRP) channels arguably represent today’s most extensively reviewed pharmacological targets. The literature on TRP channels is vast and still growing: It has exploded from a mere 21 papers in 1995 to over 2,000 in the past 2 years. Yet, even the most studied TRP channels like TRPV1 continue to surprise: as Bernd Nilius points it
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