Tuberculosis
Tuberculosis has plagued mankind since prehistoric times and is still an important source of morbidity and mortality, with particularly devastating effects in developing and tropical countries. Tuberculosis results from an infection with Myeo baeterium t
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Editors R.W. Compans, Atlanta/Georgia M. Cooper, Birmingham/Alabama H. Koprowski, Philadelphia/Pennsylvania F. Melchers, Basel M. Oldstone, La Jolia/California S. Olsnes, Oslo M. Potter, Bethesda/Maryland H. Saedler, Cologne P.K. Vogt, La Jolia/California H. Wagner, Munich
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Tuberculosis Edited by T.M. Shinnick
With 46 Figures
,
Springer
THOMAS M. SHINNICK, Ph.D. Chief, Immunology and Molecular Pathogenesis Section Division cf AIDS, STD, and TB Laboratory Research Centers for Disease Contra I and Prevention Department of Health and Human Services Atlanta, GA
30333
USA Cover illustration: Tuberculosis results from a long series of interactions between Mycobacterium tuberculosis, macrophages, and the host's immune system, some of which are schematical/y represented in the cover design. The disease process begins with the inhalation of aerosolized particles containing 1-3 viable tubereie ba eil/i. Once in the alveolar space in the lower lung, the baeilli are ingested by alveolar macrophages and most are destroyed. However, some survive phagocytosis and replicate intracel/ularly. The large bacterial burden eventually kil/s the alveolar macrophages, and the released bacilli are ingested by other alveolar macrophages or by blood borne monocytes. At this early stage of the infection, there is relatively little tissue destruction or cell death. Also, at this stage the ba eil/i-laden macrophages can leave the initial site of infection to interact with other components of the immune system and to transport the bacilli to the upper regions of the lung. In the upper lobe, the baeil/i multiply and granulomas are formed as part of the cel/ular immune response to the tubereie ba eil/i. As the infection progresses, the center of the granuloma liquefies to form a caseous necrotic lesion or tubereie the classic cavitary lesion of tuberculosis. Ultimately, the lesion ruptures into the nearby bronchi, the baeil/i discharged through the airway, and the infectious process begins anew.
Cover design: Design & Production, Heide/berg ISSN
0070-217X
ISBN-13: 978-3-642 -80168-6 e-ISBN-13: 978-3- 642-80166-2 DO I: 10.1007/978-3-642-80166-2 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm er in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from SpringerVerlag. Violations are liable for prosecution und er the German Copyright Law.
© Springer-Verlag Berlin Heidelberg 1996 Softcover reprint of the hardcover 1st edition 1996 Ubrary of Congress Catalog Card Number 15 - 12910 The use of general descriptive names, registered names, trad
