Tuberculosis
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Glossary
Tropical-Cluster Diseases Definition Tropical‐Cluster Diseases are a group that comprises several, though not all, of the diseases that are only or mostly present in the tropical area of the word. The diseases included are precisely: Trypanosomiasis (also known as sleeping sickness), Chagas disease (the Americas version of trypanosomiasis), Schistosomiasis (sometimes called bilharziasis), Leishmaniasis (kala azar or black fever), Lymphatic filariasis (elephantiasis), Onchocerciasis (river blindness).
Trypanosoma brucei Definition Trypanosoma brucei is a parasite belonging to the genus Trypanosoma and transmitted by a tsetse fly. The species Trypanosoma brucei is traditionally divided into three subspecies, Trypanosoma brucei brucei, Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. The parasites are morphologically indistinguishable. T.b. brucei is not pathogenic for humans. T.b. rhodesiense causes East African sleeping sickness and T.b. gambiense causes West African sleeping sickness.
indoleamine-2,3-dioxygenase (IDO) and indoleamine-pyrrole 2,3-dioxygenase-like 1 (INDOL 1). Tryptophan is converted to Nformyl-kynurenine by oxidation, resulting in cleavage of the five-membered indole ring.
Tryptophan Deprivation Definition Tryptophan Deprivation by indoleamine2,3-dioxygenase represents a very important mechanism to inhibit/slow down the proliferation of pathogens as well as of Tlymphocytes.
Tsetse Fly Definition Genus of biting flies feeding exclusively on blood. Different species are involved in the transmission, not only of East and West African sleeping sickness, but also of animal trypanosomiasis, causing substantial economic damage to the affected regions.
TUAG ▶ Timed Up and Go Test
Tryptophan Tuberculosis Definition Tryptophan is an essential amino acid, which is required for protein synthesis. Furthermore tryptophan serves as precursor for neurotransmitter serotonin and nicotinamide dinucleotide.
Tryptophan Degradation Definition Three enzymes catalyze tryptophan degradation: Tryptophan 2,3-dioxygenase (TDO),
Definition Infectious disease caused by Mycobacterium tuberculosis.
Tuberculosis Testing (Purified Protein Derivative, PPD) and/ or QuanteFERON Gold Definition Tests for occult or hidden TB infection within the body.
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