Tumor Maximum Area May Determine the Survival Outcomes of Patients with Thymic Epithelial Tumors
- PDF / 646,536 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 85 Downloads / 183 Views
ORIGINAL ARTICLE – THORACIC ONCOLOGY
Tumor Maximum Area May Determine the Survival Outcomes of Patients with Thymic Epithelial Tumors Dong Tian, MD, PhD1,2,3 , Haruhiko Shiiya, MD, PhD1,4, Masaaki Sato, MD, PhD1, and Jun Nakajima, MD, PhD1 1
Department of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan; 2Department of Thoracic Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, China; 3Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China; 4Department of Cardiovascular and Thoracic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
ABSTRACT Background. The tumor maximum area (TMA) of thymic epithelial tumors (TETs) is not mentioned in current staging systems. This study aimed to assess whether TMA is of prognostic significance in TETs. Methods. Patients who underwent extended thymectomy for TETs from 2001 to 2019 at our institute were retrospectively reviewed. TMA was examined by computed tomography imaging prior to surgery. Time-dependent receiver operating characteristic (ROC) curves were used to divide the cohort into two groups. The relationships between the TMA and clinicopathological characteristics or survival outcomes were assessed. Cox proportional hazards models were used to identify independent prognostic factors. Results. A total of 122 TET patients were included for evaluation, with a median age of 61 years (range 27–83). The time-dependent ROC curve indicated that the difference in 10-year overall survival (OS) was most significant for a TMA of 1392 mm2 (area under the curve 0.793); therefore, the two groups of larger (n = 40) and smaller (n = 82) TMAs were divided. The differences in adjuvant
Electronic supplementary material The online version of this article (https://doi.org/10.1245/s10434-020-09127-9) contains supplementary material, which is available to authorized users. Ó Society of Surgical Oncology 2020 First Received: 12 June 2020 Accepted: 19 August 2020 J. Nakajima, MD, PhD e-mail: [email protected]
therapy, TNM stage, and disease progression between the two groups were significant (p \ 0.05). Kaplan–Meier curves indicated that TET patients with a larger TMA had worse survival outcomes, including OS, progression-free survival (PFS) and disease-free survival (DFS) [p \ 0.05]. TMA was demonstrated to be an independent prognostic factor of all of the above survival outcomes in multivariate analysis (p \ 0.05). Conclusions. A larger TMA is associated with a more advanced TNM stage and disease progression in TET patients and may indicate worse survival outcomes, even if more patients receive adjuvant therapy.
Thymic epithelial tumors (TETs) are rare thoracic neoplasms that have an incidence of approximately 1.3–3.2/ 106 individuals;1,2 however, more than 50% of anterior mediastinal tumors are diagnosed as TETs.3 The histologic heterogeneity of TETs results in controversy and uncertainty regarding the best predictors of survival outcomes.4 Many retrospective case seri
Data Loading...
