Tumors of the Central Nervous System, Volume 1 Gliomas: Glioblastoma
The most recent developments in diagnostic and therapeutic aspects of Gliomas (Glioblastoma) in the brain are presented. The importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various type
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Tumors of the Central Nervous System Volume 1
For other titles published in this series, go to www.springer.com/series/8812
Tumors of the Central Nervous System Volume 1
Tumors of the Central Nervous System Gliomas: Glioblastoma (Part 1) Edited by
M.A. Hayat Distinguished Professor Department of Biological Sciences, Kean University, Union, NJ, USA
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Editor M.A. Hayat Department of Biological Sciences Kean University Union, NJ, USA [email protected]
ISBN 978-94-007-0343-8 e-ISBN 978-94-007-0344-5 DOI 10.1007/978-94-007-0344-5 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2011923069 © Springer Science+Business Media B.V. 2011 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Although touched by technology, surgical pathology always has been, and remains, an art. Surgical pathologists, like all artists, depict in their artwork (surgical pathology reports) their interactions with nature: emotions, observations, and knowledge are all integrated. The resulting artwork is a poor record of complex phenomena. Richard J. Reed MD
Preface
It is recognized that scientific journals not only provide current information but also facilitate exchange of information, resulting in rapid progress. In this endeavor, the main role of scientific books is to present current information in more detail after careful additional evaluation of the investigational results, especially those of new or relatively new methods and their potential toxic side-effects. Although subjects of diagnosis, drug development, therapy and its assessment, and prognosis of tumors of the central nervous system, cancer recurrence, and resistance to chemotherapy are scattered in a vast number of journals and books, there is need of combining these subjects in single volumes. An attempt will be made to accomplish this goal in the projected six-volume series of handbooks. In the era of cost-effectiveness, my opinion may be a minority perspective, but it needs to be recognized that the potential for false-positive or false-negative interpretation on the basis of a single laboratory test in clinical pathology does exist. Interobservor or intraobservor variability in the interpretation of results in pathology is not uncommon. Interpretive differences often are related to the relative importance of the criteria being used. Generally, no test always performs perfectly. Although there is no perfect remedy to this problem, standardized classifications with written definitions and guidelines will help. Standardization of methods to achieve objectivity is imperative in this effo
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