Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid
- PDF / 482,066 Bytes
- 6 Pages / 595.276 x 790.866 pts Page_size
- 57 Downloads / 167 Views
SHORT COMMUNICATION
Twin study shows association between monocyte chemoattractant protein‑1 and kynurenic acid in cerebrospinal fluid Viktoria Johansson1,2 · Sophie Erhardt3 · Göran Engberg3 · Magdalena Kegel3 · Maria Bhat4 · Lilly Schwieler3 · Kaj Blennow5,6 · Henrik Zetterberg5,7,8 · Tyrone D. Cannon9,10 · Lennart Wetterberg11 · Christina M. Hultman1,12 · Mikael Landén1,5 Received: 10 April 2019 / Accepted: 3 July 2019 © The Author(s) 2019
Abstract Preclinical studies indicate a link between the kynurenine pathway and monocyte chemoattractant protein-1 (MCP-1), but there is a lack of clinical studies examining this further. We here perform a secondary analysis of kynurenine metabolites and MCP-1 in cerebrospinal fluid of 23 twins affected from schizophrenia, bipolar disorder or unaffected. We show an association between MCP-1 and kynurenic acid (KYNA), driven by unique environmental influences and a less pronounced association between MCP-1 and tryptophan. No association was detected between MCP-1 and quinolinic acid. Further studies on the mechanism behind the putative relationship between KYNA and MCP-1 are needed. Keywords Twin study · Cerebrospinal fluid · Biomarker · Kynurenic acid · Monocyte chemoattractant protein-1 · Chemokine ligand 2
Introduction The kynurenine pathway is the major route for tryptophan (TRP) degradation and gives rise to neuroactive compounds like kynurenic acid (KYNA) and quinolinic acid (QUIN), Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00406-019-01042-9) contains supplementary material, which is available to authorized users. * Viktoria Johansson [email protected] 1
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, 171 77 Stockholm, Sweden
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Stockholm County Council, Norra Stationsgatan 69, 11364 Stockholm, Sweden
2
displaying neuroprotective and neurotoxic properties, respectively [1]. Abnormalities in the kynurenine pathway have been linked to numerous brain disorders [2], including psychiatric disorders such as schizophrenia and bipolar disorder [3]. Monocyte chemoattractant protein 1 (MCP-1), also known as chemokine ligand 2 (CCL2), is involved in the recruitment of macrophages to infection sites within the 6
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden
7
Department of Neurodegenerative Disease, Institute of Neurology, University College London, Queen Square, London, UK
8
UK Dementia Research Institute, London, UK
9
Department of Psychology, Yale University, New Haven, CT, USA
10
3
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
11
4
Protein Diagnostics, Precision Medicine and Genomics, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden
Department of Clinical
Data Loading...
