Ultrasmall Nanoparticle ROS Scavengers Based on Polyhedral Oligomeric Silsesquioxanes
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POLYMER SCIENCE
https://doi.org/10.1007/s10118-020-2486-7 Chinese J. Polym. Sci.
Ultrasmall Nanoparticle ROS Scavengers Based on Polyhedral Oligomeric Silsesquioxanes Zhan Lia, Haotian Lia, Jianhua Zhanga,b, Xianhu Liuc, Zhipeng Gua*, and Yiwen Lia* a College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China b School of Materials Science and Engineering, Xihua University, Chengdu 610039, China c National Engineering Research Center for Advanced Polymer Processing Technology, Zhengzhou University, Zhengzhou 450002, China
Electronic Supplementary Information Abstract Although tremendous efforts have been devoted to the structural and functional tailoring of natural polyphenol-functionalized nanoparticles, preparing ultrasmall sized (< 6 nm) particles with precisely-defined structures has remained a grand challenge. In this work, we reported the preparation of ultra-small and precisely structured polyhedral oligomeric silsesquioxanes (POSS)-based polyphenol nanoparticles (T8-, T10-, and T12-GAPOSS) by accurately functionalizing the POSS surface with plant polyphenol gallic acid units via thiol-Michael “click” reactions. Those polyphenol nanoparticles exhibited strong free radical scavenging capacity, good biocompatibility and ability to resist cell oxidative damage, which demonstrated great potentials in inhibiting oxidative stress induced pathologies. Keywords Polyhedral oligomeric silsesquioxanes (POSS); Polyphenol; Ultrasmall nanoparticles; Free radical scavenging Citation: Li, Z.; Li, H.; Zhang, J.; Liu, X.; Gu, Z.; Li, Y. Ultrasmall nanoparticle ROS scavengers based on polyhedral oligomeric silsesquioxanes. Chinese J. Polym. Sci. https://doi.org/10.1007/s10118-020-2486-7
INTRODUCTION Oxidation stress is a crucial factor causing a series of pathological states due to irreversible oxidative damage of biological macromolecules and cell membranes.[1−3] When suffering illness or injury, the accumulation of reactive oxygen species (ROS) often exceeds the antioxidant capacity of the cells which need exogenous antioxidants to maintain the balance of redox in cells. Antioxidant nanoparticles with excellent free radical scavenging capacity have been regarded as the main therapeutic agents against oxidative stress damage over the past few decades. Nature can offer the sources and inspirations of antioxidants towards creating various nanomaterial ROS scavengers. For example, ubiquitous natural polyphenols could exhibit excellent antioxidation and free radical scavenging features, which could inspire the further design of biomimetic antioxidant materials based on a large variety of natural polyphenol building blocks.[4−11] One convenient way relied on the surface fabrication of established nanomaterials with natural polyphenol elements to construct nanoantioxidants with strong free radical scavenging capacity for inhibiting oxidative stressinduced diseases.[12−18] It was found that their antioxidant capacit
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