Ultrasound Based Computational Fluid Dynamics Assessment of Brachial Artery Wall Shear Stress in Preeclamptic Pregnancy
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Cardiovascular Engineering and Technology (Ó 2020) https://doi.org/10.1007/s13239-020-00488-6
Original Article
Ultrasound Based Computational Fluid Dynamics Assessment of Brachial Artery Wall Shear Stress in Preeclamptic Pregnancy RYAN J. PEWOWARUK,1 JENNA RACINE,2 J. IGOR IRURETAGOYENA,2 and ALEJANDRO ROLDA´N-ALZATE1,3,4 1
Biomedical Engineering, University of Wisconsin – Madison, Madison, USA; 2Maternal and Fetal Medicine, University of Wisconsin – Madison, Madison, USA; 3Mechanical Engineering, University of Wisconsin – Madison, Madison, USA; and 4 Radiology, University of Wisconsin – Madison, Madison, USA (Received 18 March 2020; accepted 24 September 2020) Associate Editor David Elad oversaw the review of this article.
Abstract Purpose—Preeclampsia (PE) is a pregnancy complication of abnormally elevated blood pressure and organ damage where endothelial function is impaired. Wall shear stress (WSS) strongly effects endothelial cell morphology and function but in PE the WSS values are unknown. WSS calculations from ultrasound inaccurately assume cylindrical arteries and patient specific computational fluid dynamics (CFD) typically require time-consuming 3D imaging such as CT or MRI. Methods—Two-dimensional (2D) B-mode ultrasound images were lofted together to create simplified three-dimensional (3D) geometries of the brachial artery (BA) that incorporate artery curvature and non-circular cross sections. This process was efficient and on average took 120 ± 10 s. Patient specific CFD was then performed to quantify BA WSS for a small cohort of PE (n = 5) and normotensive pregnant patients (n = 5) and compared against WSS calculations assuming a cylindrical artery. Results—For several WSS metrics (time averaged WSS (TAWSS), peak systolic WSS, oscillatory shear index (OSI), OSI/TAWSS and relative residence time) CFD on the simplified arterial geometries calculated large spatial differences in WSS that assuming a cylindrical artery cannot calculate. Bland–Altman and intra-class correlation (ICC) analyses found assuming a cylindrical artery both underestimated (p < 0.05) and had poor agreement (ICC < 0.5) with the maximum WSS values from CFD. WSS values that were abnormal compared to the normotensive patients (OSI = 0.014 ± 0.026) appear related to the pregnancy complications fetal growth restriction (n = 2, OSI = 0.14, 0.25) and gestational diabetes (n = 1, OSI = 0.23). Conclusion—Creating 3D artery geometries from 2D ultrasound images can be used for CFD simulations to calculate WSS from ultrasound without assuming cylindrical arteries.
Address correspondence to Alejandro Rolda´n-Alzate, Biomedical Engineering, University of Wisconsin – Madison, Madison, USA. Electronic mail: [email protected]
This approach requires minimal time for both medical imaging and CFD analysis. Keywords—Preeclampsia, Endothelial dysfunction, Vascular disease, Pregnancy.
ABBREVIATIONS CFD PE WSS BA NT TAWSS OSI RRT
Computational fluid dynamics Preeclampsia Wall shear stress Brachial artery Normotensive Time average wall shear stress Oscillato
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