Characterizing placental stiffness using ultrasound shear-wave elastography in healthy and preeclamptic pregnancies
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MATERNAL-FETAL MEDICINE
Characterizing placental stiffness using ultrasound shear‑wave elastography in healthy and preeclamptic pregnancies Michail Spiliopoulos1 · Che‑Ying Kuo2,3,4 · Avinash Eranki3 · Marni Jacobs5 · Christopher T. Rossi6 · Sara N. Iqbal1 · John P. Fisher2,4 · Melissa H. Fries1 · Peter C. W. Kim7 Received: 23 April 2020 / Accepted: 9 July 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose To measure the stiffness of the placenta in healthy and preeclamptic patients in the second and third trimesters of pregnancy using ultrasound shear-wave elastography (SWE). We also aimed to evaluate the effect of age, gestational age, gravidity, parity and body mass index (BMI) on placental stiffness and a possible correlation of stiffness with perinatal outcomes. Methods In a case–control study, we recruited a total of 47 singleton pregnancies in the second and third trimesters of which 24 were healthy and 23 were diagnosed with preeclampsia. In vivo placental stiffness was measured once at the time of recruitment for each patient. Pregnancies with posterior placentas, multiple gestation, gestational hypertension, chronic hypertension, diabetes, autoimmune disease, fetal growth restriction and congenital anomalies were excluded. Results The mean placental stiffness was significantly higher in preeclamptic pregnancies compared to controls in the third trimester (difference of means = 16.8; 95% CI (9.0, 24.5); P
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