Ultrasound-guided muscle biopsy: a practical alternative for investigation of myopathy
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TECHNICAL REPORT
Ultrasound-guided muscle biopsy: a practical alternative for investigation of myopathy Anish Raithatha 1 & Mohammad Reza Ashraghi 2 & Christopher Lord 1 & Clara Limback-Stanic 3 & Stuart Viegas 2 & Dimitri Amiras 1 Received: 24 January 2020 / Revised: 9 May 2020 / Accepted: 24 May 2020 # The Author(s) 2020
Abstract Objective We propose the use of ultrasound-guided muscle biopsy as a viable method of obtaining muscle specimen to aid the diagnosis of myopathy. We retrospectively review the diagnostic accuracy and patient feedback of ultrasound-guided muscle biopsies in our neuromuscular service. Method Multidisciplinary team meeting reviewed select patients and agreed on those suitable for ultrasound-guided muscle biopsy. They then underwent biopsy using direct ultrasound guidance and a modified Bergström needle. The specimens were sent for histopathological analysis, and patients were given a feedback form. Results Ten patients underwent 11 ultrasound-guided muscle biopsies. Of these 11, one was processed incorrectly, but all others were good quality specimens suitable for analysis. All 10 of those processed correctly aided diagnosis. All patient feedback was rated good or excellent. In 4 patients with a previous unsuccessful surgical biopsy, ultrasound-guided biopsy was successful in obtaining suitable muscle. Of those 4 patients, 3 preferred ultrasound-guided biopsy, and 1 did not state a preference. Discussion Our ultrasound-guided muscle biopsy technique offers a viable alternative to surgical biopsy. It yields high-quality specimen that aids diagnosis and receives good feedback from patients. It can be performed quickly as a day case and does not require theatre space. Furthermore, direct visualization of structures minimizes the risk of complications and allows biopsy of otherwise difficult to access targets. Conclusion Utilization of ultrasound guided–modified Bergström needle technique for muscle biopsy provides comparable success rates to other techniques and has practical, clinical, operational, and patient-centred benefits compared with alternative techniques. Keywords Myopathy . Muscle . Biopsy . Ultrasound
Introduction Muscle biopsy is an essential diagnostic procedure in the investigation of the diagnosis of myopathy [1]. Muscle biopsies to aid the diagnosis of neuromuscular pathology require careful preservation of cellular architecture. In the UK, both
* Dimitri Amiras [email protected] 1
Department of Imaging, Imperial College Healthcare NHS Trust, London, UK
2
Neuromuscular Unit, Department of Neurology, Imperial College Healthcare NHS Trust, London, UK
3
Department of Cellular Pathology, Imperial College Healthcare NHS Trust, London, UK
percutaneous needle and open surgical biopsy are utilized. Both can be done as day-case procedures under local anaesthetic unless there are mitigating circumstances. Each has its own advantages and disadvantages [2]. The latter are the preferred choice in our institute as they provide a greater tissue yield, which is particularly imp
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