Ultrastructural Mechanisms of Impaired Aldosterone Synthesis in Rats Exposed to DDT during Prenatal and Postnatal Develo
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Bulletin of Experimental Biology and Medicine, Vol. 170, No. 1, November, 2020
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MORPHOLOGY AND PATHOMORPHOLOGY Ultrastructural Mechanisms of Impaired Aldosterone Synthesis in Rats Exposed to DDT during Prenatal and Postnatal Development N. V. Yaglova, S. S. Obernikhin, V. V. Yaglov, D. A. Tsomartova, S. V. Nazimova, and E. P. Timokhina
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 7, pp. 121-125, July, 2020 Original article submitted March 27, 2020 The study is aimed at elucidation of ultrastructural mechanisms underlying impaired aldosterone synthesis by glomerulosa cells in Wistar rats exposed to low doses of endocrine disrupter DDT during prenatal and postnatal development. Analysis of rat zona glomerulosa histology and function during the pubertal and postpubertal periods showed that exposure to endocrine disrupter DDT disturbs its development and reduced the production of aldosterone. Electron microscopy showed that changes in the aldosterone synthesis are related to impaired reorganization of the mitochondrial apparatus, one of the leading factors in the regulation of steroidogenesis, in glomerulosa cells in DDT-exposed rats during puberty. Key Words: aldosterone; endocrine disrupter; DDT; mitochondrion; secretion Aldosterone produced by adrenal zona glomerulosa ensures the maintenance of water and electrolyte balance and plays an important role in the functioning of the cardiovascular system. Its secretion is regulated by the potassium concentration in the blood controlled by the renin—angiotensin system, and to a lesser extent, by ACTH released by the pituitary gland [5]. There are ample data that recent increase in the incidence of metabolic diseases cannot be completely explained by an increase in calorie intake, low physical activity, lack of sleep, or aging. Among environmental factors involved in the global deterioration of metabolic health, endocrine disruptors attract much attention [6,8,10]. Endocrine disruptors can modulate aldosterone secretion by interfering various regulatory mechanisms, as well as by direct influence on the secretory apparatus of cells. We previously studied the ultrastructure and Research Institute of Human Morphology, Moscow, Russia. Address for correspondence: [email protected]. N. V. Yaglova
cytophysiology of adrenal glomerulosa cells and aldosterone production in rats exposed to low doses of endocrine disrupter DDT from the first day of postnatal development [2,4]. However, exposure to endocrine disrupters starts from the moment of fertilization and can impair the program of development of various organs. In this context, the main changes in the morphogenesis of endocrine glands caused by prenatal and postnatal exposure to endocrine disruptors should be studied and the mechanisms underlying functional disturbances in endocrine system should be elucidated. We studied ultrastructural mechanisms underlying impaired synthesis aldosterone by glomerulosa cells in rats exposed to endocrine disrupter DDT during prenatal and postnatal develop
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