Over-nutrient environment during both prenatal and postnatal development increases severity of islet injury, hyperglycem
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ORIGINAL PAPER
Over-nutrient environment during both prenatal and postnatal development increases severity of islet injury, hyperglycemia, and metabolic disorders in the offspring Lei Li & Jing Xue & Hongyan Li & Jian Ding & Yanyun Wang & Xietong Wang
Received: 4 March 2015 / Accepted: 28 May 2015 # University of Navarra 2015
Abstract Prenatal and postnatal over-nutrition has emerged as a new health issue contributing to metabolic disorders in early development of the offspring. Accumulating evidence has suggested that adverse prenatal and postnatal environments gave rise to the predisposition to metabolic syndromes including hyperglycemia, obesity, and diabetes. However, little research has concentrated on the effects of exposures to both adverse conditions before and after birth of the offspring. In this study, we aimed to investigate whether prenatal and postnatal over-nutrition is able to cause metabolic disorders to female mice feed on high-fat/ fructose diet (HFFD) as well as their offspring. Female mice were fed on either HFFD or a normal chow diet (NC), while their offspring were divided into four experimental groups as NC/NC, HFFD/NC, NC/HFFD, and HFFD/HFFD (prenatal/postnatal diet order), respectively. Both NC/HFFD and HFFD/HFFD offspring exhibited obvious body weight and fat content
gain, hyperglycemia, and severe insulin resistance. Interestingly, when compared to NC/HFFD offspring, the HFFD/HFFD offspring exhibited more severe alterations in their metabolism and dysfunctions on pancreatic β-cells, suggesting a potential impact of prenatal HFFD on the programming of pancreatic β-cell deficiency in the fetus. Meanwhile, the results from HFFD/NC mice indicated that a balance diet after birth partially compensated the adverse prenatal HFFD impact. In conclusion, this study demonstrated that prenatal and postnatal over-nutrition increases severity of islet injury, hyperglycemia, and metabolic disorders in the offspring.
L. Li : H. Li : Y. Wang : X. Wang (*) Department of Obstetrics, Shandong Provincial Hospital Affiliated to Shandong University, No. 324 Jingwu Road, Jinan 250021 Shandong, China e-mail: [email protected]
Individuals with body mass index (BMI) above 25 kg/m2 are more prone to morbidity of hypertension, coronary heart disease, and non-insulin-dependent type II diabetes mellitus (T2DM) [14]. In addition to genetic defects, over-nutrition was suspected as another critical factor contributing to obesity and T2DM [7, 14, 47]. Recently, maternal malnutrition, defined as either nutrient deficiency or over-nutrition during pregnancy, has attracted great concern due to its potential fetal predisposition to metabolic syndrome in adulthood [4, 11, 22, 28], which may contribute to the epidemic of obesity and T2DM.
J. Xue Department of Gynaecology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021 Shandong, China J. Ding Maternal and Child Health Hospital of Shandong Province, Jinan 250025 Shandong, China
Keywords Over-nutrient environment . Metabolic disorders . Hy
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