Use of clays using ursolic acid with anti-inflammatory activity
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Use of clays using ursolic acid with anti-inflammatory activity M.L. Domínguez-Patiño1,*, M.Chávez-Castillo2 and A. Rodríguez-Martínez3 1
Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001,
CP 62209,Cuernavaca, Morelos, México. 2
Posgrado en Ingeniería y Ciencias Aplicadas, Universidad Autónoma del Estado de Morelos, Av. Universidad
1001, CP 62209,Cuernavaca, Morelos, México. 3
Centro de Investigación en Ingeniería y Ciencias Aplicadas, Universidad Autónoma del Estado de Morelos, Av.
Universidad 1001, CP 62209, Cuernavaca, Morelos, México.
ABSTRACT Today the company seeks alternative natural medicine that are compatible with the body, which does not produce side effects and hang time are easily accessible and cost of those who currently have. The concern of researchers and specialists in the development of new materials is to seek, to experiment and create products that can be useful and compatible with human beings so as to obtain a curative effect without a side effect originates. The development of pharmacologically active materials has increased in recent years. People lack access to most drugs and is therefore a need for more rapid and less expensive than current, which can be applied to cellular systems in vitro, in order to evaluate the biocompatibility of new materials. The current study seeks to experiment in a new line of research that helps health care and have a better quality of life. The excipients in the drug are auxiliary substances that help the active ingredient is the one with the therapeutic action, can be formulated in an effective and pleasant for the patient. It is one or more substances that are incorporated into the product to facilitate its preparation, maintenance or administration. We therefore tested clay known as bentonite to serve as a vehicle for transport of an active substance (ursolic acid) [1] and some scientific studies have shown that it possesses anti-inflammatory, antibacterial, antifungal and highly cytotoxic capacity. Both materials were mixed to generate a new biomaterial that has anti-inflammatory activity. Evaluation of this model was under the inhibition of edema produced by 13-acetate-12-orthotetradecanoylphorbol (TPA) in mouse ear. INTRODUCTION While we can find a documented history of application of different materials in the implementation of therapeutic and surgical techniques before the Christian era in ancient Egypt, systematic and planned research in the area comes after the Second World War. In the decade of the 50 recorded a significant increase in numbers of cases of empirical adaptation of conventional materials in medical applications involving surgeons motivated by the existence of millions of war invalids and encouraged by the discovery of antibiotics [2]. Thereafter there is an evolution from the search for materials initially considered inert towards today called biocompatible (acceptable) with limited shelf life. The advancement of knowledge in general (biology, chemistry, physics and elec
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