Use of olfactory ensheathing cells as candidates for transplant-mediated repair of central nervous system lesions
The rat olfactory system is a tissue of extreme interest. It has the capacity to support axonal outgrowth throughout the life of the animal and more specifically can maintain continual growth of olfactory axons during natural turnover and also after injur
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Springer-Verlag Wien GmbH
Dr. Michael Sticherling Klinik uod Poliklinik fiir Hautkrankheiteo Leipzig Leipzig, Federal Republic of Germany Universitătsklinikum
Dr. Dr. h.c. Enno Christophers Klinik Îur Dermatologie, Venerologie und Aliergologie Kiel Kiel, Federal Republic of Germany
Universitătsklinikum
Printing was supported by the German Society of Autoimmune Diseases, e.V. This work is subject to copyright. Ali rights are reserved, whether the whole or part of the material is concemed, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machines or similar means, and storage in data banks. Product Liability: The publisher can give no guarantee for ali the information contained in this book. This does also refer to information about drug dosage and application thereof. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. The use of registered names, trademarks, etc., in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. © 2003 Springer-Verlag Wien Originally published by Springer-Verlag Wien New York in 2003 Softcover reprint of the hardcover Ist edition 2003
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With 32 Figures
ISBN 978-3-7091-7288-9 DOI 10.1007/978-3-7091-6016-9
ISBN 978-3-7091-6016-9 (eBook)
Foreword
Under normal circumstances, our immune system is able to distinguish between friend and foe and does not attack the body's own tissues. Unfortunately, this is not always the case. Sometimes the immune system reacts to harmless substances like plant pollen and thus triggers allergic reactions. More serious, however, are autoimmune reactions, which destroy the body's own tissue. Autoimmune disorders may in principal affect any human organ. They therefore have many different clinical faces. Depending on where this attack occurs in the body, different diseases appear. Some antigens and tissues, however, are more frequently involved than others: with regard to multiple sclerosis this is myelin basic protein among different other central nervous system components, in rheumatoid arthritis the innerjoint lining and in diabetes mellitus the insulin-producing cells of the pancreas. In systemic lupus erythematosus, skin, kidneys and various other organs are targeted. These are only examples. In fact, currently there are more than 60 different autoimmune disorders known and 5% of all adults in Europe and North America suffer from one or more autoimmune disorders. Despite these facts, autoimmune disorders do not attract ample attention neither in the public nor in scientific research. In particular, scientifically based clinical trials on autoimmune disorders are relatively underrepresented because of missing financial support. In addition, autoimmune disorders occu
