Usefulness of sialic acid for diagnosis of sepsis in critically ill patients: a retrospective study
- PDF / 984,349 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 101 Downloads / 196 Views
RESEARCH ARTICLE
Open Access
Usefulness of sialic acid for diagnosis of sepsis in critically ill patients: a retrospective study Bo Yao1,2, Wen-juan Liu2, Di Liu2, Jin-yan Xing2* and Li-juan Zhang1*
Abstract Background: Early diagnosis of sepsis is very important. It is necessary to find effective and adequate biomarkers in order to diagnose sepsis. In this study, we compared the value of sialic acid and procalcitonin for diagnosing sepsis. Methods: Newly admitted intensive care unit patients were enrolled from January 2019 to June 2019. We retrospectively collected patient data, including presence of sepsis or not, procalcitonin level and sialic acid level. Receiver operating characteristic curves for the ability of sialic acid, procalcitonin and combination of sialic acid and procalcitonin to diagnose sepsis were carried out. Results: A total of 644 patients were admitted to our department from January 2019 to June 2019. The incomplete data were found in 147 patients. Finally, 497 patients data were analyzed. The sensitivity, specificity and area under the curve for the diagnosis of sepsis with sialic acid, procalcitonin and combination of sialic acid and procalcitonin were 64.2, 78.3%, 0.763; 67.9, 84.0%, 0.816 and 75.2, 84.6%, 0.854. Moreover, sialic acid had good values for diagnosing septic patients with viral infection, with 87.5% sensitivity, 82.2% specificity, and 0.882 the area under the curve. Conclusions: Compared to procalcitonin, sialic acid had a lower diagnostic efficacy for diagnosing sepsis in critically ill patients. However, the combination of sialic acid and procalcitonin had a higher diagnostic efficacy for sepsis. Moreover, sialic acid had good value for diagnosing virus-induced sepsis. Keywords: Sepsis, Sialic acid, Procalcitonin, Virus, Bacteria, Corona virus disease 2019
Background Sepsis is common in the ICU. Approximately 35% of critically ill patients in the ICU meet the criteria for sepsis. In addition, the mortality of sepsis patients is high, approximately 33.1% [1]. The required timing for finishing sepsis bundles changes from 3 h to 1 h now [2]. This shows the importance of timing for sepsis treatment. For example, antimicrobial therapy is recommended in 1 h sepsis bundles. A delay in starting antimicrobial therapy * Correspondence: [email protected]; [email protected] 2 The department of Critical Care Medicine, The affiliated hospital of Qingdao University, Wutaishan road 1677, Qingdao city 26600, China 1 Systems Biology and Medicine Center, The affiliated hospital of Qingdao University, Wutaishan road 1677, Qingdao city 26600, China
is associated with high mortality [3]. Therefore, early sepsis diagnosis is very important. In the clinic, procalcitonin (PCT), as a biomarker, is widely used for the early diagnosis of sepsis. However, its pooled sensitivities and specificities were not higher than 0.80 in a recent metaanalysis study [4]. Therefore, it is necessary to find more effective and adequate biomarkers to diagnose sepsis. Serum sialic acid (SA), as a common cli
Data Loading...
