Value of endometrial thickness change after human chorionic gonadotrophin administration in predicting pregnancy outcome
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GYNECOLOGIC ENDOCRINOLOGY AND REPRODUCTIVE MEDICINE
Value of endometrial thickness change after human chorionic gonadotrophin administration in predicting pregnancy outcome following fresh transfer in vitro fertilization cycles Jialyu Huang1 · Jiaying Lin1 · Hongyuan Gao1 · Jing Zhu1 · Xuefeng Lu1 · Ning Song2 · Renfei Cai1 · Yanping Kuang1 Received: 10 March 2020 / Accepted: 24 August 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose To study whether the change of endometrial thickness (EMT) between the day of human chorionic gonadotrophin (hCG) administration and the day of embryo transfer has any impact on pregnancy outcome in fresh in vitro fertilization/ intracytoplasmic sperm injection (IVF/ICSI) cycles. Methods This single-center retrospective cohort study included 2620 patients undergoing their first consecutive autologous IVF/ICSI cycles from January 2003 to December 2012. Patients were categorized into three groups based on the percentage change of post-hCG EMT: > 10% decrease, ± 10% plateau and > 10% increase. The primary outcome was live birth rate. Results Live birth rates were similar in the EMT decrease, plateau and increase groups (27.4% [174/635], 29.7% [300/1010] and 27.6% [269/975]; P = 0.649). Compared with the plateau group, both EMT decrease (crude odds ratio [cOR] 0.89, 95% confidence interval [CI] 0.72–1.11) and increase (cOR 0.90, 95% CI 0.74–1.10) on the day of transfer did not affect the likelihood of live birth. The non-significant association was maintained after controlling for major confounding factors, with the adjusted OR being 0.92 (95% CI 0.73–1.16) and 0.92 (95% CI 0.75–1.13) for the decrease and increase groups, respectively. Conclusion EMT change after hCG administration did not provide significant prognostic information for pregnancy outcome in fresh IVF/ICSI cycles. This finding should offer reassuring information for patients with decreased EMT on the day of embryo transfer while questioning the necessity of EMT re-measurement prior to transfer as a routine practice. Keywords Endometrial thickness · Pregnancy · In vitro fertilization · Embryo transfer
Introduction
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00404-020-05763-4) contains supplementary material, which is available to authorized users. * Renfei Cai [email protected] * Yanping Kuang [email protected] 1
Department of Assisted Reproduction, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Rd., Shanghai 200011, China
Department of Histology, Embryology, Genetics and Developmental Biology, Shanghai Key Laboratory for Reproductive Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
2
The application of in vitro fertilization (IVF) for infertility treatment has been on a constant increase since Louise Brown was born in 1978 [1, 2]. However, the likelihood of obtaining a pregnancy still remains modest following IVF cycles, des
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