The effect of letrozole versus artificial hormonal endometrial preparation on pregnancy outcome after frozen-thawed embr
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(2020) 18:115
RESEARCH
Open Access
The effect of letrozole versus artificial hormonal endometrial preparation on pregnancy outcome after frozen-thawed embryos transfer cycles: a randomized clinical trial Azadeh Hosseini-Najarkolaei1, Ashraf Moini1,2,3* , Ladan Kashani1, Maryam Farid Mojtahedi1,4, Elnaz Hosseini-Najarkolaee5,6 and Ensieh Salehi7
Abstract Background: Considering that clinical trial studies are limited in polycystic ovary syndrome (PCOS) patients, and there is no consensus on an optimum endometrial preparation protocol for frozen embryo transfer (FET), the present study was designed as a randomized clinical trial to compare the reproductive outcomes following stimulated cycles with letrozole plus human menopausal gonadotropin (HMG) for endometrial preparation compared with routine AC-FET. Methods: This randomized controlled trial was carried out on infertile PCOS patients who underwent IVF/ICSI and FET cycles in Arash Women’s Hospital affiliated to Tehran University of Medical Sciences between September 2018 and January 2020. PCOS diagnosis was based on the Rotterdam criteria. Eligible patients were randomly allocated into two groups: stimulated cycle with letrozole plus (HMG) (intervention group) and routine artificial hormonal endometrial preparation (control group). Results: One hundred seventy-seven infertile patients were recruited for participation in the study. Of these, 57 women were excluded due to non-eligibility for entering the study, and a total of 120 patients were randomly assigned to two study groups. After follow up, the cycle outcomes of 57 patients in the intervention group and 59 patients in the control group were compared. The data analysis showed that the two groups did not have significant differences in fundamental and demographic characteristics. After the intervention, there were no significant differences in implantation rate, chemical, ectopic, and clinical pregnancy rates between groups. Moreover, the rates of miscarriage and ongoing pregnancy were similar between groups (P > 0.05). (Continued on next page)
* Correspondence: [email protected] 1 Department of Gynecology and Obstetrics, Arash women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran 2 Breast Disease Research Center (BDRC), Tehran University of Medical Sciences, Tehran, Iran Full list of author information is available at the end of the article
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