Value of volumetric and textural analysis in predicting the treatment response in patients with locally advanced rectal
- PDF / 1,596,425 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 101 Downloads / 164 Views
ORIGINAL ARTICLE
Value of volumetric and textural analysis in predicting the treatment response in patients with locally advanced rectal cancer Nazlı Pınar Karahan Şen1 · Ayşegül Aksu1 · Gamze Çapa Kaya1 Received: 19 June 2020 / Accepted: 10 September 2020 © The Japanese Society of Nuclear Medicine 2020
Abstract Objective The aim of this study was to assess the value of baseline 18F-FDG PET/CT in predicting the response to neoadjuvant chemo-radiotherapy (NCRT) in patients with locally advanced rectal cancer (LARC) via the volumetric and texture data obtained from 18F-FDG PET/CT images. Methods In total, 110 patients who had undergone NCRT after initial PET/CT and followed by surgical resection were included in this study. Patients were divided into two groups randomly as a train set (n: 88) and test set (n: 22). Pathological response using three-point tumor regression grade (TRG) and metastatic lymph nodes in PET/CT images were determined. TRG1 were accepted as responders and TRG2-3 as non-responders. Region of interest for the primary tumors was drawn and volumetric features (metabolic tumor volume (MTV) and total lesion glycolysis (TLG)) and texture features were calculated. In train set, the relationship between these features and TRG was investigated with Mann–Whitney U test. Receiver operating curve analysis was performed for features with p
Data Loading...
