Vasomotorische Symptome in der Menopause
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eilung für Gynäkologische Endokrinologie und Sterilitätstherapie, Universitätsklinik für Frauenheilkunde, Wien, Österreich
Vasomotorische Symptome in der Menopause
Originalpublikation
Originalpublikation
Crandall C J, Diamant AL, Maglione M, Thurston RC, Sinsheimer J (2020) Genetic Variation and Hot Flashes: A Systematic Review. J Clin Endocrinol Metab 105(12):dgaa536. https:// doi.org/10.1210/clinem/dgaa536
Falbová D, Vorobeľová L, Čerňanová VC, Beňuš R, Wsólová L, Siváková D (2020) Association of cytochrome P450 1B1 gene polymorphisms and environmental biomarkers with hypertension in Slovak midlife women. Menopause 27(11):1287–1294. https://doi.org/10.1097/ GME.0000000000001605
Abstract Original-Abstract (The Journal of Clinical Endocrinology & Metabolism): https://academic.oup.com/jcem/articleabstract/105/12/dgaa536/5892804
Für die Praxis Laut dieser Metanalyse scheint es einen Zusammenhang zwischen dem Tachykininrezeptor 3 Gen und vasomotorischen Symptomen in der Menopause zu geben, während eine Assoziation mit dem CYP1B1 Gen statistisch nicht signifikant war. Bei dem Tachykininrezeptor 3 Gen gibt es allerdings 14 Nukleotidvarianten – die Autoren weisen zu Recht darauf hin, dass es mehr Studien zu diesem Thema braucht.
Abstract1 Objective. This study investigated the association of the Leu432Val and Asn453Ser CYP1B1 polymorphisms and selected environmental biomarkers with hypertension ( HT) in Slovak midlife women. Methods. We studied 575 women. Divided according to their blood pressure status: 255 with HT and 320 without HT. All data was obtained by using standard anthropometric, genetic methods and analyzed by regression models to adjust for HT risk factors such as age, obesity, smoking, and level of education. Results. Our findings revealed that CYP1B1 Leu432Val polymorphism was associated with H T, whereas no association was found between Asn453Ser polymorphism and H T. Women with at least one Val allele had significantly higher odds of HT compared to women with Mit Genehmigung aus: Falbová D, Vorobeľová L, Čerňanová VC, Beňuš R, Wsólová L, Siváková D. Association of cytochrome P450 1B1 gene polymorphisms and environmental biomarkers with hypertension in Slovak midlife women. Menopause. 2020 Nov;27(11):1287–1294; https://journals.lww.com/menopausejournal/ Abstract/2020/11000/Association_of_cytochrome_P450_1B1_gene.14.aspx © 2020 by The North American Menopause Society
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Journal für Gynäkologische Endokrinologie/Österreich 4 · 2020
the Leu/Leu genotype in the total sample (Exp(B) = 1.82, CI 1.16–2.84, P = 0.009). After dividing women by menopausal status and the presence of H T environmental risk factor, the association between CYP1B1 polymorphism and HT was observed in pre/perimenopausal women (Exp(B), 2.36; 95 % CI 1.13–4.92; P = 0.02), smokers (Exp(B), 3.40; 95 % CI 1.48–7.82; P = 0.004), abdominal obesity (Exp(B), 2.41; 95 % CI 1.23–4.75; P = 0.01) and in women with only basic education (Exp(B), 4.20, 95 % CI 1.12– 15.71; P = 0.03). However, general linear models di
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