Vertebrate Eye Development

The power of molecular genetics has recently returned the discipline of Developmental Biology to its original position at the forefront of biological research. The vertebrate eye was one of the classic embryologic models in the early 1900s. Within the las

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w.

Hennig, L. Nover, U. Scheer

31

Springer-Verlag Berlin Heidelberg GmbH

M. Elizabeth Fini (Ed.)

Vertebrate Eye Development With 37 Figures

Springer

M.

ELIZABETH FINI, PH.

D.

Vision Research Laboratories New England Eye Center Tufts University School of Medicine 750 Washington Street, Box 450 Boston, MA 02111 USA

ISBN 978-3-642-53678-6 ISBN 978-3-540-46826-4 (eBook) DOI 10.1007/978-3-540-46826-4 Library of Congress Cataloging-in-Publication Data Vertebrate eye develop men tiM. Elizabeth Fini. p. em - (Results and Problems in Cell Differentiation; 31) Includes bibliographical references (p.). 1. Eye-Growth. 2. Eye-Differentiation. 3. Eye-Cytology. 4. Developmental biology. 1. Fini, M. Elizabeth. II. Series.

QP475.V 472000 573.8'816-dc21 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law.

© Springer-Verlag Berlin Heidelberg 2000 Originally published by Springer-Verlag Berlin Heidelberg New Yark in 2000 Softcover reprint of the hardcover 1st edition 2000 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.

Cover design: Meta Design, Berlin Typesetting: Scientific Publishing Services (P) Ltd, Madras SPIN: 10697053 39/3136 - 5 4 3 2 1 0 - Printed on acid-free paper

Acknowledgements

The Editor wishes to acknowledge two of her previous fellows, Judith WestMays, PhD and Katherine Strissel, PhD, for their significant contribution to her education in eye development, and expresses gratitude to her chairman, Carmen A. Puliafito, MD, MBA, for creating a situation that made this education possible. Thanks are also extended to Ms Laoti Russo for her expert editorial assistance. This project was supported by grants from the National Eye Institute (EY09828 and EY12651) and from the National Institute of Arthritis, Musculoskeletal, and Skin Diseases (AR42981). The Editor is a Jules and Doris Stein Research to Prevent Blindness Professor. Boston, January 2000 M. Elizabeth Fini

Preface

"Who would believe that so small a space could contain the images of all the universe?" Leonardo da Vinci

The last years of the 20th century have found the discipline of Developmental Biology returning to its original position at the forefront of biological research. This progress can be attributed to the burgeoning knowledge base on molecules and gene families, and to the power of the mo