Virus Coinfection is a Predictor of Radiologically Confirmed Pneumonia in Children with Bordetella pertussis Infection
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ORIGINAL RESEARCH
Virus Coinfection is a Predictor of Radiologically Confirmed Pneumonia in Children with Bordetella pertussis Infection Wujun Jiang . Min Wu . Sainan Chen . Anrong Li . Kun Wang . Yuqing Wang . Zhengrong Chen . Chuangli Hao . Xuejun Shao . Jun Xu
Received: October 12, 2020 / Accepted: November 19, 2020 Ó The Author(s) 2020
ABSTRACT Introduction: This study aimed to prospectively investigate the burden of pertussis in southeast Chinese children hospitalized with lower respiratory tract infection (LRTI) during a pertussis outbreak and to compare the outcomes of Bordetella pertussis infection with or without virus coinfections. Methods: Children \ 24 months of age hospitalized with LRTI were prospectively enrolled from January 2017 to December 2019. Demographic and clinical information were recorded, and respiratory tract samples were tested for the presence of B. pertussis and ten common viruses by polymerase chain reaction (PCR).
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s40121020-00376-5) contains supplementary material, which is available to authorized users. W. Jiang M. Wu S. Chen A. Li K. Wang Y. Wang (&) Z. Chen C. Hao Department of Respiratory Medicine, Children’s Hospital of Soochow University, Suzhou, China e-mail: [email protected] W. Jiang Department of Medicine, Children’s Hospital of Wujiang District, Suzhou, China X. Shao J. Xu Department of Clinical Laboratory, Children’s Hospital of Soochow University, Suzhou, China
Results: Bordetella pertussis PCR was positive in 6.1% (202/4287) of the patients. Only 146 (72.3%) B. pertussis infections met the Centers for Disease Control and Prevention case definition for pertussis. Among the 202 subjects with B. pertussis infections, 81 (40.1%) were coinfected with at least 1 respiratory virus, with human rhinovirus being the most commonly detected virus (25.7%). No differences in clinical severity were observed between children with single B. pertussis infection and those with virus coinfection [odds ratio (OR) 0.75; 95% confidence interval (CI) 0.39–1.44]. However, children with virus coinfection were significantly more likely to present with radiologically confirmed pneumonia than those with a single B. pertussis infection (OR 2.62; CI 1.39–4.91). Conclusions: Bordetella pertussis infection contributed to a high proportion of LRTI hospitalizations among southeast Chinese children. There were no significant differences in clinical severity between children with virus coinfection and single B. pertussis infection, although children coinfected with virus coinfection presented with pneumonia more frequently than those with single B. pertussis infection. Keywords: Clinical Pertussis; Virus
outcome;
Coinfection;
Infect Dis Ther
Key Summary Points Why carry out this study? Bordetella pertussis infection results in significant morbidity and mortality in children and its re-emergence has been the focus of international attention. However, due to limited laboratory routine pe
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