Is Helicobacter pylori infection associated with Henoch-Schonlein purpura in Chinese children? a meta-analysis
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Is Helicobacter pylori infection associated with HenochSchonlein purpura in Chinese children? a meta-analysis Li-Jing Xiong, Yu Tong, Zhi-Ling Wang, Meng Mao Chengdu, China
Methods: Predefined search strategy and inclusion criteria were set up to select studies reporting the prevalence of H. pylori infection among HSP children and control groups. Included studies were subjected to quality assessment and data extraction by two independent reviewers. The pooled odds ratio (OR) was calculated as the effect size via both traditional and cumulative meta-analysis. Heterogeneity was investigated by subgroup analysis, and the nonparametric "trim and fill" method was performed to adjust the overall estimate for the existence of publication bias. Results: Ten eligible studies covering 749 HSP children and 560 controls were included for metaanalysis. Observational epidemiology studies clearly aimed at detecting the potential association between H. pylori infection and HSP with retrospective data
Author Affiliations: Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China (Xiong LJ, Tong Y, Wang ZL, Mao M); Laboratory of Early Developmental and Injuries, West China Institute of Woman and Children's Health, West China Second University Hospital, Sichuan University, Chengdu, China (Xiong LJ, Tong Y, Mao M); Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Chengdu 610041, China (Xiong LJ, Tong Y, Mao M) Corresponding Author: Meng Mao, MD, Department of Pediatrics, West China Second University Hospital, Sichuan University, No.20 Renmin South Road (SectionIII), Chengdu 610041, China (Email: dffmmao@126. com) doi: 10.1007/s12519-012-0373-1 ©Children's Hospital, Zhejiang University School of Medicine, China and Springer-Verlag Berlin Heidelberg 2012. All rights reserved.
collection from the children enrolled consecutively. Overall, 49.27% (369/749) of HSP children had evidence of H. pylori infection compared with 23.39% (131/560) of children in the control group. The pooled OR of H. pylori infection in HSP children (10 studies with 749 HSP children) was 3.80 [95% confidence interval (CI): 2.54-5.68, P
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