Vitamin C in Human Health and Disease Effects, Mechanisms of Action,

This book presents the scientific evidence for the role of vitamin C in health and disease and offers new guidance on vitamin C intake in humans. The importance of vitamin C in preventing cancer and cardiovascular disease, its relevance to aging and stres

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Vitamin C in Human Health and Disease Effects, Mechanisms of Action, and New Guidance on Intake

Vitamin C in Human Health and Disease

Wang Jae Lee

Vitamin C in Human Health and Disease Effects, Mechanisms of Action, and New Guidance on Intake

Wang Jae Lee Department of Anatomy Seoul National University College of Medicine Seoul, South Korea

ISBN 978-94-024-1711-1    ISBN 978-94-024-1713-5 (eBook) https://doi.org/10.1007/978-94-024-1713-5 © Springer Nature B.V. 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature B.V. The registered company address is: Van Godewijckstraat 30, 3311 GX Dordrecht, The Netherlands

Preface

More than 30 years have been passed since I first made vitamin C part of my life. I think it was my great good fortune to be introduced to vitamin C as a medical doctor, for I have been able to lead a healthier life by regularly taking large amounts of vitamin C. In addition, I have performed countless experiments on vitamin C using animals, especially gulo(−/−) mice, which, like humans, cannot synthesize this vitamin. These experiments, published in some 40 papers in recognized international journals over the last few decades, have served to identify the effects of vitamin C on each of the human body systems, including the cardiovascular, nervous, gastrointestinal, immune, endocrine, and respiratory systems, and have sometimes even elucidated the detailed mechanisms involved. In most scientific books, chapters are co-authored, but I have chosen to write this book as the sole author because I dare to declare myself a “vitamin C specialist”. Moreover, throughout my career I have lectured on the structure of the human body as an anatomy professor, and I consequently believe that I have a deep understanding of the whole human body. I do not regard this book as pu