Nitrite and Nitrate in Human Health and Disease

Nitrite and Nitrate in Human Health and Disease delivers a comprehensive review of nitrite and nitrate biology, from basic biochemistry to the complex physiology and metabolism of these two naturally occurring molecules in the human body.  Well-organ

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Nathan S. Bryan, Ph.D. Joseph Loscalzo, M.D., Ph.D. Editors

Nitrite and Nitrate in Human Health and Disease

Editors Nathan S. Bryan, Ph.D. Brown Foundation Institute of Molecular Medicine The University of Texas Health Science Center at Houston Houston, TX USA [email protected]

Joseph Loscalzo, M.D., Ph.D. Department of Medicine Brigham and Women’s Hospital and Harvard Medical School Boston, MA USA [email protected]

Series Editor Adrianne Bendich, Ph.D., FACN President, Consultants in Consumer Healthcare, LLC Morristown, NJ USA [email protected]

ISBN 978-1-60761-615-3 e-ISBN 978-1-60761-616-0 DOI 10.1007/978-1-60761-616-0 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011925549 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)

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The great success of the Nutrition and Health Series is the result of the consistent overriding mission of providing health professionals with texts that are essential because each includes: 1) a synthesis of the state of the science, 2) timely, in-depth reviews by the leading researchers in their respective fields, 3) extensive, up-to-date fully annotated reference lists, 4) a detailed index, 5) relevant tables and figures, 6) identification of paradigm shifts and the consequences, 7) virtually no overlap of information between chapters, but targeted, inter-chapter referrals, 8) suggestions of areas for future research, and 9) balanced, data-driven answers to patient as well as health professionals questions which are based upon the totality of evidence rather than the findings of any single study. The Series volumes are not the outcome of a symposium. Rather, each editor has the potential to examine a chosen area with a broad perspective, both in subject matt