Weight-Based Dosing Versus a Fixed-Dose Regimen of 4-Factor Prothrombin Complex Concentrate in Obese Patients Requiring
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ORIGINAL RESEARCH ARTICLE
Weight‑Based Dosing Versus a Fixed‑Dose Regimen of 4‑Factor Prothrombin Complex Concentrate in Obese Patients Requiring Vitamin K Antagonist Reversal Pansy Elsamadisi1 · Mark A. G. Cepeda1 · Tuyen Yankama1 · Adrian Wong1,2 · Qua Tran1 · Ifeoma Mary Eche1 Accepted: 19 September 2020 © Springer Nature Switzerland AG 2020
Abstract Introduction Despite an increase in the use of fixed-dose protocols of 4-factor prothrombin complex concentrate (4F-PCC) for the reversal of vitamin K antagonists (VKAs), there remains a paucity of data in obese patients. In this study, we aimed to compare the proportion of patients attaining international normalized ratio (INR) goals using a weight-based dosing strategy versus a fixed-dose regimen of 4F-PCC. Methods This was a retrospective study conducted in patients 18 years of age or older, weighing ≥ 100 kg, who received either a weight-based dose or fixed dose of 4F-PCC (2000 units) for the reversal of VKA, and had a documented baseline and post-treatment INR. The primary outcome was the proportion of patients achieving an INR of
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