106 Weight loss in type 2 diabetes mellitus is associated with decreased myocardial triglyceride content and improved le
- PDF / 350,703 Bytes
- 2 Pages / 610 x 792 pts Page_size
- 8 Downloads / 161 Views
BioMed Central
Open Access
Meeting abstract
106 Weight loss in type 2 diabetes mellitus is associated with decreased myocardial triglyceride content and improved left ventricular function Sebastiaan Hammer*, Marieke Snel, Ingrid M Jazet, Rutger W van der Meer, Johannes A Romijn, Hanno Pijl, Edo Meinders, Johannes WA Smit, Albert de Roos and Hildo J Lamb Address: Leiden University Medical Center, Leiden, The Netherlands * Corresponding author
from 11th Annual SCMR Scientific Sessions Los Angeles, CA, USA. 1–3 February 2008 Published: 22 October 2008 Journal of Cardiovascular Magnetic Resonance 2008, 10(Suppl 1):A7
doi:10.1186/1532-429X-10-S1-A7
Abstracts of the 11th Annual SCMR Scientific Sessions - 2008
Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1532-429X-10-S1-info.pdfThis abstract is available from: http://jcmr-online.com/content/10/S1/A7 © 2008 Hammer et al; licensee BioMed Central Ltd.
Introduction Obesity and type 2 diabetes mellitus (DM2) are risk factors for cardiovascular disease. Weight loss improves myocardial left ventricular systolic and diastolic function and glycemic control. In healthy subjects myocardial triglyceride (TG) pools have proven to be flexible, associated with changes in myocardial function. Whether improvements in myocardial function are associated with changes in myocardial triglyceride (TG) content in DM2 is unknown.
Purpose To determine the effects of substantial weight loss in obese DM2 patients on myocardial TG content and myocardial function.
Materials and methods Body mass index (BMI) and plasma HbA1c were determined in 9 obese, insulin treated DM2 patients (mean age ± SE: 48.2 ± 3.2 yrs) before and after 16 weeks of a very low calorie diet (VLCD, 473 kcal/day). Furthermore, myocardial TG content and left ventricular (LV) function were determined using proton magnetic resonance spectroscopy and MRI respectively at 1.5 T (Gyroscan ACS/NT15, Philips). During the intervention all insulin and other anti diabetic treatment were stopped. The percentage (%) of myocardial TG was calculated as TG/water × 100. Myocardial function was calculated as cardiac output (CO)
and ejection fraction (EF). In addition LV mass, blood pressure and diastolic ratio between the early and atrial filling phase (E/A ratio) were determined.
Results BMI decreased from 35.8 ± 1.5 at baseline to 27.6 ± 5.0 kg/m2 (P < 0.001) after substantial weight loss (mean decrease: -25.6 ± 1.5 kg), and was associated with a significant improvement in HbA1c (from 7.8 ± 0.6 to 6.1 ± 0.4%, P < 0.05). Myocardial %TG at baseline was 0.74 ± 0.10% and decreased to 0.42 ± 0.32% after substantial weight loss (P < 0.05, Fig. 1A). CO decreased from 7790 ± 577 to 6552 ± 402 ml at baseline and after substantial weight loss respectively (P < 0.05). LV mass decreased from 119 ± 9 g at baseline to 101 ± 7 g after weight loss (P < 0.01, Fig. 1B). Ejection fraction was unchanged after substantial weight loss. Systolic and diastoli
Data Loading...
