[ 18 F]FDG Uptake in Adipose Tissue Is Not Related to Inflammation in Type 2 Diabetes Mellitus
- PDF / 1,452,349 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 2 Downloads / 151 Views
RESEARCH ARTICLE
[18F]FDG Uptake in Adipose Tissue Is Not Related to Inflammation in Type 2 Diabetes Mellitus Melanie Reijrink ,1 Stefanie A. de Boer,1 Ines F. Antunes,2 Daan S. Spoor,2 Hiddo J. L. Heerspink,3 Monique E. Lodewijk,4 Mirjam F. Mastik,4 Ronald Boellaard,2,5 Marcel J. W. Greuter,6,7 Stan Benjamens,2 Ronald J. H. Borra,2,7,8 Riemer H. J. A. Slart,2,9 Jan-Luuk Hillebrands,4 Douwe J. Mulder1 1
Department of Vascular Medicine, University of Groningen, University Medical Center Groningen, HP AA41, Hanzeplein 1, 9700RB, Groningen, The Netherlands 2 Department of Nuclear Medicine and Molecular Imaging, Medical Imaging Center, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands 3 Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands 4 Department of Pathology and Medical Biology, Division of Pathology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands 5 Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center-VU Medical Center, Amsterdam, the Netherlands 6 Department of Robotics and Mechatronics Biomedical Technology and Technical Medicine (MIRA), University of Twente, Enschede, the Netherlands 7 Department of Radiology, Medical Imaging Center, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands 8 Department of Diagnostic Radiology, Medical Imaging Centre of Southwest Finland, University of Turku, Turku University Hospital, Turku, Finland 9 Department of Biomedical Photonic Imaging, Faculty of Science and Technology, University of Twente, Enschede, the Netherlands
Abstract Purpose: 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) uptake is a marker of metabolic activity and is therefore used to measure the inflammatory state of several tissues. This radionuclide marker is transported through the cell membrane via glucose transport proteins (GLUTs). The aim of this study is to investigate whether insulin resistance (IR) or inflammation plays a role in [18F]FDG uptake in adipose tissue (AT). Procedures: This study consisted of an in vivo clinical part and an ex vivo mechanistic part. In the clinical part, [18F]FDG uptake in abdominal visceral AT (VAT) and subcutaneous AT (SAT) was determined using PET/CT imaging in 44 patients with early type 2 diabetes mellitus (T2DM) (age 63 [54–66] years, HbA1c [6.3 ± 0.4 %], HOMA-IR 5.1[3.1–8.5]). Plasma levels were
Jan-Luuk Hillebrands and Douwe J. Mulder contributed equally to this work. Electronic supplementary material The online version of this article (https:// doi.org/10.1007/s11307-020-01538-0) contains supplementary material, which is available to authorized users. Correspondence to: Melanie Reijrink; e-mail: [email protected]
Reijrink M. et al.: [18F]FDG and Adipose Tissue Inflammation in Diabetes Mellitus
measured with ELISA. In the mechanistic part, AT biopsies obtained from 8 patients were ex vivo incubated with [18F]FDG followed by autoradio
Data Loading...
