A Study on Impact of BPA in the Adipose Tissue Dysfunction (Adiposopathy) in Asian Indian Type 2 Diabetes Mellitus Subje
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ORIGINAL RESEARCH ARTICLE
A Study on Impact of BPA in the Adipose Tissue Dysfunction (Adiposopathy) in Asian Indian Type 2 Diabetes Mellitus Subjects Jyoti Jain1 • Nidhi Gupta2 • Rati Mathur1 • Surendra Nimesh3 • Sandeep K. Mathur4
Received: 27 February 2019 / Accepted: 10 July 2019 Ó Association of Clinical Biochemists of India 2019
Abstract A surge to increase the production via usage of chemicals at both industrial and agricultural arena has forced humans to be routinely and imprudently exposed to a wide variety of endocrine disrupting chemicals. The overall aim of the study was to evaluate possible relation that might exist between bisphenol-A (BPA) and the adipose tissue hormones, and further impact on adiposopathy. In the present study, the role of BPA, an ‘‘endocrine disruptor’’ with respect to adiposopathy was evaluated in type 2 diabetes mellitus patients. For the study, 150 healthy control subjects and 150 newly diagnosed diabetes patients were recruited. Fasting venous blood samples was analyzed for several biochemical parameters such as serum glucose, lipid profile, insulin, adiponectin, leptin, TNF-a, IL-6, IL1, free fatty acid. Concentrations of BPA were also measured both in control and diabetic subjects. Serum BPA concentration was found to be significantly higher in diabetic subjects in comparison to the control subjects. Levels of BPA were found to be positively correlated with BMI and WC in diabetic subjects. Also, it was found to be Jyoti Jain and Nidhi Gupta contributed equally as first authors. & Sandeep K. Mathur [email protected] 1
Department of Biochemistry, SMS Medical College and Hospital, Jaipur, Rajasthan, India
2
Research and Development Cell, Department of Biotechnology, IIS (Deemed to be University), Jaipur, Rajasthan, India
3
Department of Biotechnology, School of Life Sciences, Central University of Rajasthan, Bandar Sindri, N.H. 8, Kishangarh, Ajmer, Rajasthan, India
4
Department of Endocrinology, SMS Medical College and Hospital, Jaipur, Rajasthan 302004, India
positively correlated with leptin and negatively correlated with adiponectin in diabetic subjects. Therefore, the current study suggested more deleterious effect of BPA on diabetes and its pathophysiology. Keywords Bisphenol-A Adiposopathy Type 2 diabetes mellitus Endocrine disruptors Adipose tissues
Introduction With changing lifestyle, obesity and diabetes are emerging as huge public health crisis and threatening the economies of all nations, particularly developing countries. According to International Diabetes Federation (IDF), in 2015 about 415 million people had diabetes mellitus worldwide. This figure is projected to be 642 million by the year 2040. South Asians have a disproportionately higher incidences of type-2 diabetes mellitus (T2DM) and it occurs at 50% higher rates in them as compared to other racial groups [1]. Diabetes develops 5–10 years earlier in them and is one of the principle causes of premature heart attack and death. According to IDF, there were 69.2 million diabeti
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