2010 EuroMeeting Student Poster Abstracts
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2010 EuroMeeting Student Poster Abstracts 'Ihe fdlowing are the accepted Student Poster Session Abstmcts as of the press date of this issue. Ihe student posters will be on display at the DIA 22nd Annual EuroMeeiing, March 8-10, Grimaldi Forum, Monaco. Ihe poster review
Placebo Effect in Children Miss Vinciane Cabot Eudipharm, Lyon, France Obj ective Placebo effect seems more important in children than adults as suggested in partial epilepsy and in migraine trials. Consequently, establishing efficacy of drug interventions might be more challenging in children. Method We reviewed all placebo controlled systematic reviews enrolling both children and adults published in the Cochrane database. No limit on the type of disease or drug intervention was used. Results From a total of 972 systematic reviews, 53 met our inclusion criteria. We compared treatment versus placebo effect in adult versus children using Meta-regression technique. Conclusion It might be necessary to increase the size of future pediatric trials to ensure enough power. Protective Effects of Pioglitazone in the Model of Adriamycin-Induced Nephropathy Miss Hana Cernecka Comenius University, Bratislava, Slovakia Objective We studied the effects of pioglitazone in experimental model of adriamycin nephropathy. Method After induction of endothelial dysfunction and nephropathy using adriamycin (2.5 mg/kg i.v.), rats were treated with pioglitazone. Vascular function, renal tissue damage and changes in proteinuria were assessed. Results Adriamycin reduced aortic relaxation and caused massive proteinuria and renal damage. Pioglitazone normalized endothelial function, decreased proteinuria and reduced structural renal damage.
committee will select the winning posters on Tuesdq, March 9 at 5:30 PM in the Exhibition Hall. Ihe winning authors will receive a EuroMeeting Student Poster prize.
Conclusion Pioglitazone reduced adriamycin induced endothelial and renal dysfunction in rat.
Decision Analysis of Three Rate-Control Agents in the 'hatment of Atrial Fibrillation in Elderly or Sedentary Patients Ms. Theresa Doan Research Assistant, University of Houston College of Pharmacy, Houston, Texas Objective Conduct cost-minimization analysis among three recommended drugs (digoxin, diltiazem, and metoprolol) for rate control for patients with atrial fibrillation (AF) from a third-party payer's perspective. Method A decision model to calculate total cost per day was developed using values from national statistics, payer reimbursement rates, and published studies. Results Metoprolol was the least expensive drug ($319/ day) compared to diltiazem ($481/day) and digoxin ($605/day). Metoprolol resulted in a net cost savings of $162 and $286 per patient compared to diltiazem and digoxin, respectively. Conclusion For elderly or sedentary patients with AF, metoprolo1 seems to be cost-effective as initial therapy. Further evaluation is needed to consider long-term outcomes and costs between the drugs.
How to Deal With Regression to the Mean (RTM) in Clinical 'Ikials? Miss M
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