203 Correlation of myocardial T2 and T2 measurements in thalassemia patients
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Meeting abstract
203 Correlation of myocardial T2 and T2 measurements in thalassemia patients Taigang He*, Peter D Gatehouse, Gillian C Smith, Raad H Mohiaddin, Dudley J Pennell and David N Firmin Address: Royal Brompton Hospital and Imperial College London, London, UK * Corresponding author
from 11th Annual SCMR Scientific Sessions Los Angeles, CA, USA. 1–3 February 2008 Published: 22 October 2008 Journal of Cardiovascular Magnetic Resonance 2008, 10(Suppl 1):A64
doi:10.1186/1532-429X-10-S1-A64
Abstracts of the 11th Annual SCMR Scientific Sessions - 2008
Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1532-429X-10-S1-info.pdfThis abstract is available from: http://jcmr-online.com/content/10/S1/A64 © 2008 He et al; licensee BioMed Central Ltd.
Introduction Cardiac complications secondary to iron overload are the leading cause of death in thalassemia major (TM). Both magnetic resonance imaging (MRI) T2* and T2 have been validated as non-invasive means for assessment of myocardial iron overload. While T2 is dependent on the exchanging of energy with nearby nuclei, T2* is additionally affected by magnetic field inhomogeneity. It has been hence argued that T2* may be less accurate for tissue iron quantification because of its sensitivity to shimming, susceptibility and other factors. Therefore, it is of clinical interest to investigate the relationship between tissue T2* and T2, particularly in the heart. The T2* technique has showed interstudy reproducibility [1] and interscanner transferability [2,3]. A breath-hold T2 technique has also been developed which was reproducible and demonstrated clinically relevance compared with T2* [4,5]. The recent advance of a black blood T2* technique [6] and the development of improved post processing T2* analysis routines [7,8] further improved the reproducibility and accuracy of the measurement. All these advances make it possible to reliably compare T2 and T2* measurements on a large scale of patient population, which can help better understand the relationship between T2 and T2* in iron overloaded heart hence improve the diagnosis and management in the transfusion dependent patients.
Purpose
in order to establish the relationship between them. We hypothesized that T2* will correlate with T2 linearly when iron becomes dominant in the myocardium.
Methods 132 TM patients (age 27 ± 11 years old, 64 males) were studied on a 1.5 T MRI scanner (Siemens Sonata) using a cardiac phased array coil and with ECG gating. All patients were scanned using the black blood T2* sequence and the T2 sequence subsequently, each within a breath-hold. A single mid-ventricular short axis slice was imaged with both T2* and T2 measured in the left ventricular septum (Figure 1). The mono-exponential decay model and the nonlinear curve fitting algorithm were employed for the patient data analysis [7,8] (CMRtools, Imperial College London).
Results Figure 1 demonstrates exem
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