Preferential patterns of myocardial iron deposit by multislice multiecho T2* CMR in thalassemia major patients
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BioMed Central
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Preferential patterns of myocardial iron deposit by multislice multiecho T2* CMR in thalassemia major patients Vincenzo Positano*1, Antonella Meloni1, Alessia Pepe1, Pasquale Pepe1, Maria Chiara Dell'Amico1, Brunella Favilli1, Cristina Salvatori1, Petra Keilberg1, Gennaro Restaino2, Eliana Cracolici3, Stefano Pulini4, Angela Ciancio5, Maria Filomena Santarelli1 and Massimo Lombardi1 Address: 1G Monasterio Foundation and Institute of Clinical Physiology, CNR, Pisa, Italy, 2Università Cattolica del Sacro Cuore, Campobasso, Italy, 3Policlinico "Paolo Giaccone", Palermo, Italy, 4Osped. Civile "Spirito Santo", Pescara, Italy and 5Ospedale "Madonna delle Grazie", Matera, Italy * Corresponding author
from 13th Annual SCMR Scientific Sessions Phoenix, AZ, USA. 21-24 January 2010 Published: 21 January 2010 Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):P276
doi:10.1186/1532-429X-12-S1-P276
Abstracts of the 13th Annual SCMR Scientific Sessions - 2010
Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1532-429X-11-S1-infoThis abstract is available from: http://jcmr-online.com/content/12/S1/P276 © 2010 Positano et al; licensee BioMed Central Ltd.
Introduction
Results
T2* multislice multiecho cardiac magnetic resonance (CMR) technique has permitted quantification of myocardial iron burden by a segmental approach. Little is known in the literature about patterns of iron store in hemochromatosis.
Two-hundred and twenty-nine patients showed global T2* value < 26 ms, corresponding to significant global heart iron overload. The analysis was focused on this patient population, subsequently divided into two groups: severe iron overload (N = 83, global T2* < 10 ms) and mild-moderate iron overload (N = 146, global T2* between 10 and 26 ms). For each group, segments were sorted by mean T2* value. Segment order was significantly preserved between the two groups (r = 0.91, P < 0.0001). Significant circumferential variability was found in patients with overall heart iron overload (figure 1A) as well as in both groups (P < 0.0001). The mean T2* value over the anterior region was significantly lower than the mean T2* values over the other regions and the mean T2* over the inferior region was significantly lower than the T2* values over the septal and lateral regions (figure 1B). This pattern was preserved within each single slice (figure 1C). We found a significantly higher T2* value in the basal slice vs the medium and apical slices in patients with severe iron overload.
Purpose Our study aimed to investigate myocardial iron overload in thalassemia major (TM) patients by segmental T2* CMR technique, in order to determine if there were preferential patterns of iron deposit.
Methods Five hundred and nineteen TM patients underwent CMR. Three short-axis views (basal, medium, and apical) of the left ventricle were acquired and analyzed using customwritten, previously vali
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