2049 Improved detection of myocardial fibrosis using high-resolution, late gadolinium-enhanced cardiovascular magnetic r
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Meeting abstract
2049 Improved detection of myocardial fibrosis using high-resolution, late gadolinium-enhanced cardiovascular magnetic resonance in patients with hypertrophic cardiomyopathy Caitlin J Harrigan*1, Dana C Peters2, Martin S Maron3, Barry J Maron4, C Michael Gibson1, Warren J Manning1 and Evan Appelbaum1 Address: 1Perfuse CMR Core Lab, Boston, MA, USA, 2Beth Israel-Deaconnes Medical Center, Boston, MA, USA, 3Tufts-New England Medical Center, Boston, MA, USA and 4Minneapolis Heart Institute Foundation, Minneapolis, MN, USA * Corresponding author
from 11th Annual SCMR Scientific Sessions Los Angeles, CA, USA. 1–3 February 2008 Published: 22 October 2008 Journal of Cardiovascular Magnetic Resonance 2008, 10(Suppl 1):A318
doi:10.1186/1532-429X-10-S1-A318
Abstracts of the 11th Annual SCMR Scientific Sessions - 2008
Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1532-429X-10-S1-info.pdfThis abstract is available from: http://jcmr-online.com/content/10/S1/A318 © 2008 Harrigan et al; licensee BioMed Central Ltd.
Background Myocardial fibrosis as detected by late gadolinium enhanced cardiovascular MR (LGE-CMR) is common in patients with hypertrophic cardiomyopathy (HCM) although its clinical significance is uncertain. Current standard 2D LGE CMR imaging However, a recent postmortem report demonstrated an isolated foci of papillary muscle scarring which was not detected by conventional 2D LGE-CMR imaging. Three-dimensional high resolution (3D-HR) LGE CMR imaging has the potential for minimizing the partial volume (blood/papillary scar) effect of lower resolution/conventional 2D imaging and may improve our sensitivity for detecting myocardial fibrosis. Therefore, we sought to determine if 3D-HR LGECMR has a diagnostic advantage over conventional 2D LGE CMR for the detection of myocardial fibrosis in HCM patients.
Methods Our study compared standard two-dimensional LGE imaging with high resolution, three-dimensional LGE imaging for the detection of myocardial fibrosis in a cohort of patients with hypertrophic cardiomyopathy. Conventional 2D LGE-CMR were acquired 15–20 minutes post injection of 0.2 mmol/kg GdDTPA, using an ECG-triggered, 40 views per RR, 1 RR between inversions, TI adjusted to null myocardium, fat saturation, 2 × 2 × 8 (skip 2) mm true spatial resolution, 10–12 short-axis
slices, TR/TE/θ = 4.1 ms/1.7 ms/20° sequence. The 3D LGE-CMR acquisition immediately followed the 2D acquisition. Imaging parameters were the same except: respiratory motion compensation with navigator-gating, TR/TE/θ = 5.7 ms/2.8 ms/25°, 26 views per RR, with 1.4 × 1.4 × 5 mm true spatial resolution. 2D and 3D LGE-CMR images were obtained in 13 HCM subjects (35 ± 21 years; 38% male). All regions of LGE in the left ventricle (LV) and papillary muscles were assessed visually, by 2 independent readers (CJH and EA).
Results Seven (54%) of 13 HCM subjects (mean LVEF 72%, range 58–82%; maximal LV wal
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