Detection of subclinical myocardial dysfunction in cocaine addicts with feature tracking cardiovascular magnetic resonan
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(2020) 22:70
RESEARCH
Open Access
Detection of subclinical myocardial dysfunction in cocaine addicts with feature tracking cardiovascular magnetic resonance Alicia M. Maceira1,2* , Sara Guardiola1, Carmen Ripoll3, Juan Cosin-Sales4, Vicente Belloch1 and Jose Salazar5
Abstract Background: Cocaine is an addictive, sympathomimetic drug with potentially lethal effects. We have previously shown with cardiovascular magnetic resonance (CMR) the presence of cardiovascular involvement in a significant percentage of consecutive asymptomatic cocaine addicts. CMR with feature-tracking analysis (CMR-FT) allows for the quantification of myocardial deformation which may detect preclinical involvement. Therefore, we aimed to assess the effects of cocaine on the left ventricular myocardium in a group of asymptomatic cocaine users with CMR-FT. Methods: In a cohort of asymptomatic cocaine addicts (CA) who had been submitted to CMR at 3 T, we used CMR-FT to measure strain, strain rate and dyssynchrony index in CA with mildly decreased left ventricular ejection fraction (CA-LVEFd) and in CA with preserved ejection fraction (CA-LVEFp). We also measured these parameters in 30 age-matched healthy subjects. Results: There were no differences according to age. Significant differences were seen in global longitudinal, radial and circumferential strain, in global longitudinal and radial strain rate and in radial and circumferential dyssynchrony index among the groups, with the lowest values in CA-LVEFd and intermediate values in CA-LVEFp. Longitudinal, radial and circumferential strain values were significantly lower in CA-LVEFp with respect to controls. Conclusions: CA-LVEFp show decreased systolic strain and strain rate values, with intermediate values between healthy controls and CA-LVEFd. Signs suggestive of dyssynchrony were also detected. In CA, CMR-FT based strain analysis can detect early subclinical myocardial involvement. Keywords: Cocaine, Feature tracking, Subclinical dysfunction, Cardiovascular magnetic resonance, Heart failure
Background
* Correspondence: [email protected] 1 Cardiovascular Unit, Ascires Biomedical Grup, C/ Marques de San Juan Nº6, 46015, Valencia, Spain 2 Department of Medicine, Health Sciences School, CEU-Cardenal Herrera University, C/ Santiago Ramón y Cajal, s/n, 46115 Alfara del Patriarca, Moncada-Valencia, Spain Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence an
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