211 MRI of coronary vessel wall injury in a swine model of coronary intervention using an eletrostatically stabilized VS
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Meeting abstract
211 MRI of coronary vessel wall injury in a swine model of coronary intervention using an eletrostatically stabilized VSOP nanoparticle Christian von Bary1, Anne Preissel2, Susanne Wagner3, Marcus R Makowski4, Alexandra Keithahn4, Elmar Spuentrup5, Albert Schoemig1, Simon Robinson6, Joel Lazewatsky6, Markus Schwaiger4, Joerg Hausleiter1, Matthias Taupitz3 and René M Botnar*4 Address: 1Cardiology Division, Technische Universität München, Munich, Germany, 2Center for Preclinical Research, Technische Universität München, Munich, Germany, 3Diagnostic Radiology, Charite, Berlin, Germany, 4Nuclear Medicine, Technische Universität München, Munich, Germany, 5Diagnostic Radiology, Cologne University, Cologne, Germany and 6Bristol-Myers Squibb Medical Imaging, North Billerica, MA, USA * Corresponding author
from 11th Annual SCMR Scientific Sessions Los Angeles, CA, USA. 1–3 February 2008 Published: 22 October 2008 Journal of Cardiovascular Magnetic Resonance 2008, 10(Suppl 1):A72
doi:10.1186/1532-429X-10-S1-A72
Abstracts of the 11th Annual SCMR Scientific Sessions - 2008
Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1532-429X-10-S1-info.pdfThis abstract is available from: http://jcmr-online.com/content/10/S1/A72 © 2008 von Bary et al; licensee BioMed Central Ltd.
Introduction Atherosclerosis is an inflammatory disease of the vessel wall with unstable lesions being associated with the presence of inflammatory cells, smooth muscle cell apoptosis, and the accumulation of LDL. Dextran coated superparamagnetic iron oxide (SPIO) nanoparticles (~20 nm) have been shown to allow for imaging of plaque resident macrophages approximately >24 h post intravenous injection. Citrate coated very small iron oxide (VSOP) nanoparticles (~7 nm) have been found useful for steady state aortic and coronary MR angiography (MRA) but also have been shown to accumulate in advanced aortic lesions in a rabbit model of atherosclerosis.
Purpose In this study we wanted to test the hypothesis whether the combined use of an extracellular matrix specific Gd-based contrast agent (BMS753951) together with a VSOP nanoparticle would allow the exclusive visualization of the pathologically altered coronary vessel wall in an animal model of coronary intervention.
domestic swine (~30 kg). Following a one week normal diet, coronary MRA and delayed enhancement vessel wall imaging was performed using a 1.5 T Philips Achieva MR scanner. Immediately before the imaging session, animals were injected with 0.1 mmol/kg BMS753951, an elastinbinding low molecular weight Gd-based contrast agent (Bristol Myers Squibb, Billerica, MA). After localization of the heart, coronary MRA was performed using a steady state free precession imaging sequence. ~30 minutes post BMS753951 injection, delayed enhancement coronary wall imaging was performed with spatial resolution, slice thickness and image orientation maintained using an inversio
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