Coronary vessel wall assessment after Kawasaki Disease
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POSTER PRESENTATION
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Coronary vessel wall assessment after Kawasaki Disease Tarique Hussain*, Sarah Peel, Aphrodite Tzifa, Thomas Krasemann, Gerald Greil, Rene Botnar From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011 Introduction 2D cross-sectional Dual-Inversion-Recovery (DIR) blackblood imaging of the coronary arteries has been used to assess Kawasaki Disease (KD) (Greil et al. 2007). A 3D coronary black-blood approach, however, has been shown to provide better coverage of the coronary tree (Botnar et al 2001). Furthermore, uptake of gadolinium contrast agent in coronary walls may indicate on-going inflammation or vessel wall fibrosis (Maintz et al, 2006). Aim To investigate whether in-plane 3D coronary vessel wall imaging utilizing a local-inversion technique and spiral image acquisition, in combination with contrastenhanced inversion-recovery (IR) imaging allows more comprehensive assessment of KD. Methods Patients with previous coronary aneurysms due to KD undergoing routine CMR evaluation had additional vessel wall imaging before and after contrast administration (0.2 mmol/kg gadopentetate dimeglumine). All examinations were performed on a 1.5T MR-system and the coil was selected according to patient size (two-element/fiveelement). Coronary MRA was followed by a targeted, free-breathing, ECG-triggered 3D vessel wall sequence using local inversion and spiral image acquisition (spatial resolution=0.76x0.76x2mm; TE/TR=2/29ms, FA=90°). Areas of vessel wall thickening on in-plane imaging were then further evaluated with through plane 2D DIR vessel wall technique. Post-contrast imaging was performed using a freebreathing, ECG-triggered, 3D IR segmented gradientecho (TFE) sequence (spatial resolution=1.25x1.25x3mm,
King’s College London, London, UK
TE/TR=1.4/3.5ms, FA=30° & TI chosen to null blood using Look-Locker).
Results 13 CMR examinations were performed in 12 children (7 male, age=2-19yrs; HR=60-110bpm; 6 weeks-18 years post-acute KD). 6 cases showed persistent aneurysms; 4 cases had coronary ectasia and the remaining resolved aneurysms had a normal lumen. One case showed a mild LAD stenosis shown on CMRA and confirmed on conventional angiography. Complete black blood coverage of the affected portions of the coronary arteries was achieved using the new 3D in-plane local-inversion technique. Targeted 2D cross-sectional imaging showed that aneurismal segments had greater wall thickness
Figure 1 4yrs old patient (9 months post-acute KD). CMRA (1A) showing LAD aneurysm (*). 3D in-plane local inversion black blood of LAD (1B). Delayed Enhancement overlay (purple) on CMRA showing enhancement of aneurysm (1C). Green marker on 1A & 1B shows position of DIR cross-section (1D).
© 2011 Hussain et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the origina
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