3D Printed Bioelectronic Platform with Embedded Electronics
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MRS Advances © 2018 Materials Research Society DOI: 10.1557/adv.2018.431
3D Printed Bioelectronic Platform with Embedded Electronics Shweta Agarwala1, Jia Min Lee1, Wai Yee Yeong1, Michael Layani1,2, Shlomo Magdassi2 1
Singapore Centre for 3D Printing (SC3DP), School of Mechanical and Aerospace Engineering, Nanyang Technological University (NTU), 50 Nanyang Avenue, Singapore 639798
2
Institute of Chemistry, Casali Center for Applied Chemistry, Hebrew University of Jerusalem, Israel 91904
Abstract
Silver nanoparticle based microelectrodes embedded between layers of hydrogel material were successfully fabricated. 3D bioprinting is employed to print the entire bioelectronics platform comprising of conducting silver ink and Gelatin methacryloyl (GelMA) hydrogel. The additive manufacturing technique of bioprinting gives design freedom for the circuit, saves material and shortens the time to fabricate the bioelectronics platform. The silver platform shows excellent electrical conductivity, structural flexibility and stability in wet environment. It is tested for biocompatibility using C2C12 murine myoblasts cell line. The work demonstrates the potential of the fabricated platform for the realization of practical bioelectronic devices.
INTRODUCTION Flexible and embedded electronics is of huge interest for biomedical applications. Bioelectronic devices have shown promise to provide novel healthcare solutions. However, for the new-age electronics to work for biomedical field, it needs to be biocompatible. Hence, it is imperative to move away from hard and inflexible substrates such as silicon and glass. There are only few reports that have experimented with biocompatible substrates for electronics. He et al. laid down nanoparticles over textured hydrogels for large-scale micropatterning [1]. The group demonstrated that assembled particles could be transferred and integrated into alternative templates while retaining their properties for bioassays. In another effort, researchers integrated a hydrogel based microfluidic chip with Electric Cell-substrate Impedance Sensing (ECIS) technique to apply to a high-throughput, real-time cell viability assay and drug screening [2]. A passive wireless sensor was combined with a variety of hydrogel materials for biomedical and chemical sensing applications by Sridhar et al. [3]. Ahn et al. created silver nanowire based microelectrodes on a soft and biocompatible hydrogel [4]. However they used a lengthy and tedious transfer process to shift the silver nanowires from glass to hydrogel substrate.
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As the world moves towards more complex, multi-functional and flexible biomedical devices, there arises a need to explore new ways to fabricate them. Additive manufacturing (AM) commonly referred to as 3D printing, is novel manufacturing technique that helps to
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