5.19 Correlation Among Renal and Cardiac Function and Left Ventricular Geometries: The Strong Heart Study
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Heart 5.19 Correlation Among Renal and Cardiac Function and Left Ventricular Geometries: The Strong Heart Study M. De Marco (1), G. de Simone (1), M. Chinali (1), M.J. Roman (2), E.T. Lee (3), M. Russell (4), N. Shara (4), R.B. Devereux (2) ` di Napoli “Federico II”, Napoli, Italia; (2)Weill Cornell Medical (1)Universita College, New York, USA; (3)Medstar Research Phoenix, Phoenix, USA; (4)Medstar Research Institute, Hyattsville, USA Introduction. Patients with chronic kidney disease (CKD) have often cardiac alterations, but there is little information on whether the natural decline of kidney function associated with age, is also related to changes in left ventricular (LV) geometry and function. This study was undertaken to assess the relation of renal function to cardiac geometry and function in members of a population-based cohort without renal failure. Methods: We analyzed echocardiography data of 2242 echocardiography from the 4th Strong Heart Study exam (59% women; age 37±16) with estimated glomerular filtration rate (eGFR) calculated by MDRD formula >60 ml/min/1.73 m2 (excluding CKD stage 3 to 5) and without proteinuria or hyperfiltration (eGFR >150 ml/min/1.73 m2). The population was divided into quintiles of renal function, assessed by eGFR and compared by ANOVA, polynomial trend analysis was also performed. Results. As expected, negative relations of eGFR quintiles were found with age, gender, body mass index (BMI) and systolic blood pressure (BP) (all p
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