9.29 Diabetes and Incident Heart Failure: the Strong Heart Study
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High Blood Press Cardiovasc Prev 2008; 15 (3): 171-215 1120-9879/08/0003-0171/$48.00/0 © 2008 Adis Data Information BV. All rights reserved.
Metabolic Aspects and Mechanisms 9.29 Diabetes and Incident Heart Failure: the Strong Heart Study G. de Simone (1, , R.B. Devereux (2), M. Chinali (1), E.T. Lee (3), J.M. Galloway (4), A. Barac (5), J. Panza (5), B.V. Howard (5) ` di Napoli Federico II, Napoli, Italy, (2)Weill Cornell Medical College, (1)Universita New York, USA, (3)University of Oklahoma, Oklahoma City, USA, (4)University of Arizona, Tucson, USA, (5)Medstar Research Institute, Washington, USA Introduction. Although diabetes is widely accepted as a potential cause of heart failure (HF), few data exist concerning the association of diabetes with HF independent of clinically overt coronary heart disease (CHD). This study was designed to assess whether diabetes increases incidence of HF independently of prevalent and incident CHD. Methods. We studied 2740 participants (1781 women) free of prevalent CV disease or severe kidney disease at the 1st exam of the Strong Heart Study cohort. Diabetes was present in 1206 individuals (44%), and impaired fasting glucose (IFG) in 391 (14%). We evaluated 12-year incident HF. Followup HF was ascertained by End-Point Committee. Hazard of HF was evaluated using Cox regression, forcing diabetes at the end of all other covariates and treating incident myocardial infarction as a competing risk event. Results. Diabetic participants more frequently had hypertension and central obesity (both p
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